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L-Kynurenine

Catalog No. T4928 CAS 2922-83-0

Synonyms: (S)-Kynurenine

L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.

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L-Kynurenine, CAS 2922-83-0

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Purity: 98%

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Description	L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
In vitro	Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production thereby increasing tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells.
In vivo	Kynurenine dilates arteries from rats as well as humans via Kv7 channels in the vascular smooth muscle. This tryptophan metabolite causes hypotension in rats, which is partly counteracted by Kv7 channel inhibition. L-kynurenine administered 1 h before the hypoxia-ischemia shows a dose-dependent significant neuroprotective effect, with complete protection at a dose of 300 mg/kg. The induction of c-fos immunoreactivity in cerebral cortex is also blocked by this dose of L-kynurenine.

Synonyms	(S)-Kynurenine
Molecular Weight	208.21
Formula	C10H12N2O3
CAS No.	2922-83-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (240.14 mM)), Need ultrasonic

0.5M HCL: 50mg/mL

H2O: 4mg/mL(at 20°C)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kolho K L , Pessia A , Jaakkola T , et al. Faecal and serum metabolomics in paediatric inflammatory bowel disease[J]. Journal of Crohns & Colitis, 2017, 11(3):321-334. 2. Fukushima T , Iizuka H , Yokota A , et al. Quantitative Analyses of Schizophrenia-Associated Metabolites in Serum: Serum D-Lactate Levels Are Negatively Correlated with Gamma-Glutamylcysteine in Medicated Schizophrenia Patients[J]. PLOS ONE, 2014, 9. 3. Hartai Z , Klivenyi P , Janaky T , et al. Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease[J]. Journal of the Neurological Sciences, 2005, 239(1):31-35. 4. Enhanced Tryptophan Degradation in Systemic Lupus Erythematosus[J]. Immunobiology, 2000, 201(5):0-630. 5. Widner B , Sepp N , Kowald E , et al. Degradation of tryptophan in patients with systemic lupus erythematosus[J]. Oxygen Transport to Tissue XXXIII, 1999, 467:571-577. 6. Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7. 7. Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.

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Keywords

L-Kynurenine 2922-83-0 Immunology/Inflammation Metabolism Endogenous Metabolite Aryl Hydrocarbon Receptor AhR Inhibitor (S)-Kynurenine inhibit L Kynurenine LKynurenine inhibitor

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