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Metabolism Dehydrogenase LDH-IN-1

LDH-IN-1

Catalog No. T11829   CAS 1964515-43-2
Purity 99.84% Datasheet

LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).

LDH-IN-1, CAS 1964515-43-2
Pack Size Availability Price/USD Quantity
1 mg In stock 277.00
5 mg In stock 565.00
10 mg In stock 876.00
25 mg In stock 1807.00
50 mg In stock 2841.00
100 mg In stock 4082.00
1 mL * 10 mM (in DMSO) In stock 780.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
Targets&IC50 LDHA :ic50 32 nM,   LDHB :ic50 27 nM,  
In vitro LDH-IN-1 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.
Molecular Weight 570.68
Formula C30H26N4O4S2
CAS No. 1964515-43-2

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
0. Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204. 1. Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204.

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