Shopping Cart
- Remove All
Your shopping cart is currently empty
LEQ506
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
Catalog No. T11838Cas No. 1204975-42-7
Select Batch
Purity:98.53%
Contact us for more batch information
LEQ506
Catalog No. T11838Alias NVP-LEQ506Cas No. 1204975-42-7
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $370 | In Stock | |
| 25 mg | $591 | In Stock | |
| 50 mg | $798 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 500 mg | $2,150 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $273 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "LEQ506"
Halcinonide
Halcimat, Halciderm, Halcinonida, SQ-18566
T01073093-35-4
Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
- $40
Size
QTY
IHR-1
IHR 1
T24159548779-60-8
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
- $29
Size
QTY
ALLO-2
T141881357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
- $58
Size
QTY
BMS-833923
XL-139
T22991059734-66-5
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
- $29
Size
QTY
SAG
Cited
Smoothened Agonist (SAG) HCl, Smoothened Agonist
T1779912545-86-9
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
- $47
Size
QTY
CitedPurmorphamine Cited
Shh Signaling Antagonist VI
T1810483367-10-8
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
- $51
Size
QTY
CitedCyclopamine Cited
11-Deoxojervine
T28254449-51-8
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
- $48
Size
QTY
CitedMK-4101
T6891935273-79-3
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.
- $41
Size
QTY
Taladegib
LY2940680
T26661258861-20-9
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
- $35
Size
QTY
MRT-14
T95311263131-83-4
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.
- $30
Size
QTY
GI-560192
RL-0070933
T64351301326-41-0
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.
- $117
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
| Description | LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively. |
| Targets&IC50 | Smo (human):2 nM , Smo (mouse):4 nM |
| In vitro | LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2]. |
| Alias | NVP-LEQ506 |
| Molecular Weight | 432.56 |
| Formula | C25H32N6O |
| Cas No. | 1204975-42-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (231.18 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy LEQ506 | purchase LEQ506 | LEQ506 cost | order LEQ506 | LEQ506 chemical structure | LEQ506 in vitro | LEQ506 formula | LEQ506 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.