Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 163.00 | |
5 mg | In stock | $ 413.00 | |
10 mg | In stock | $ 618.00 | |
25 mg | In stock | $ 985.00 | |
50 mg | In stock | $ 1,330.00 | |
100 mg | In stock | $ 1,790.00 | |
500 mg | In stock | $ 3,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 455.00 |
Description | LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively. |
Targets&IC50 | Smo (mouse):4 nM , Smo (human):2 nM |
In vitro | LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2]. |
Synonyms | NVP-LEQ506 |
Molecular Weight | 432.56 |
Formula | C25H32N6O |
CAS No. | 1204975-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (231.18 mM)
You can also refer to dose conversion for different animals. More
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LEQ506 1204975-42-7 Stem Cells Smo Inhibitor NVP-LEQ-506 LEQ 506 Smoothened inhibit NVP-LEQ 506 LEQ-506 NVP-LEQ506 inhibitor