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LLY-507

Catalog No. T6879 CAS 1793053-37-8

Synonyms: LLY507, LLY 507

LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.

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LLY-507, CAS 1793053-37-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 140.00
25 mg	In stock	$ 321.00
50 mg	In stock	$ 581.00
100 mg	In stock	$ 829.00
1 mL * 10 mM (in DMSO)	In stock	$ 112.00

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Purity: 99.93%

Biological Description

Chemical Properties

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Description	LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
Targets&IC50	SMYD2:15 nM.
In vitro	LLY-507 effectively inhibits the ability of SMYD2 to methylate p53 peptide (IC50<15 nM). LLY-507 is able to potently inhibit the methylation of the H4 peptide by the SMYD2 enzyme (IC50: 31 nM). It has 100-fold selectivity for SMYD2 than 24 other protein or DNA methyltransferases including related family members SMYD3 and SUVH420H1/SUV420H2. LLY-507 inactive (>20 μM) against three cytochrome P450 enzymes, 14 nuclear hormone receptors, 35 G protein-coupled receptors, and 454 kinases. LLY-507 dose-dependently inhibits the proliferation of several liver, esophageal, and breast cancer cell lines.
Cell Research	To examine the methylation status of p53 in HEK293 cells treated with LLY-507 by Western blotting, 2 × 105 cells are seeded in 6-well plates in triplicate and co-transfected with FLAG-tagged p53 and FLAG-tagged SMYD2 using Lipofectamine? 2000. The day after transfection, cells are treated with 0-2.5 μM LLY-507 for 28 h, then collected, and lysed in RIPA buffer. Cell lysates are subject to 10% SDS-PAGE and transferred to a PVDF membrane.

Synonyms	LLY507, LLY 507
Molecular Weight	574.76
Formula	C36H42N6O
CAS No.	1793053-37-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (161.8 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 21 mg/mL (36.5 mM)

References and Literature

1. Nguyen H, et al. J Biol Chem. 2015, 290(22):13641-53.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Anti-Cancer Active Compound Library Epigenetics Compound Library Histone Modification Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Anti-Aging Compound Library Chromatin Modification Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LLY-507 1793053-37-8 Chromatin/Epigenetic Histone Methyltransferase protein LLY507 inhibit methyltransferase methylation breast cancer LLY 507 SMYD2 p53 Inhibitor epigenetics inhibitor

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