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LY-2584702 free base

Catalog No. T6159 CAS 1082949-67-4

LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).

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LY-2584702 free base, CAS 1082949-67-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 116.00
10 mg	In stock	$ 150.00
25 mg	In stock	$ 332.00
50 mg	In stock	$ 448.00
100 mg	In stock	$ 658.00
500 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 126.00

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Purity: 98.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
Targets&IC50	p70 S6K:4 nM
In vitro	In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM[1]. Combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus, LY2584702 has significant synergistic effects [2].
In vivo	LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

Molecular Weight	445.42
Formula	C21H19F4N7
CAS No.	1082949-67-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1 mg/mL(2.24 mM), Heating is recommended.

References and Literature

1. Hollebecque A, Houédé N, Cohen EE, Massard C, Italiano A, Westwood P, Bumgardner W, Miller J, Brail LH, Benhadji KA, Soria JC. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84. doi: 10.1016/j.ejca.2013.12.006. Epub 2014 Jan 20. 2. Hollebecque A , Houédé, Nadine, Cohen E E W , et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.[J]. European Journal of Cancer, 2014, 50(5):876-884.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Kinase Inhibitor Library Anti-Cancer Clinical Compound Library PI3K-AKT-mTOR Compound Library Reprogramming Compound Library Metabolism Compound Library Anti-Aging Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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