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LY-2584702 free base

Catalog No. T6159 CAS 1082949-67-4

LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).

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LY-2584702 free base, CAS 1082949-67-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
Targets&IC50	p70S6K:4 nM
In vitro	In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM[1]. Combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus, LY2584702 has significant synergistic effects [2].
In vivo	LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

Molecular Weight	445.426
Formula	C21H19F4N7
CAS No.	1082949-67-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 1 mg/mL(2.24 mM), warmed

DMSO: 10 mM, warmed with 50oC water bath

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tolcher A, et al. Eur J Y. 2014, 50(5), 867-875. 1. Hollebecque A, Houédé N, Cohen EE, Massard C, Italiano A, Westwood P, Bumgardner W, Miller J, Brail LH, Benhadji KA, Soria JC. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84. doi: 10.1016/j.ejca.2013.12.006. Epub 2014 Jan 20. 2. Hollebecque A , Houédé, Nadine, Cohen E E W , et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.[J]. European Journal of Cancer, 2014, 50(5):876-884.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Lung Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Stem Cell Differentiation Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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