Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 45.00 | |
2 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 107.00 | |
10 mg | In stock | $ 169.00 | |
25 mg | In stock | $ 317.00 | |
50 mg | In stock | $ 513.00 | |
100 mg | In stock | $ 743.00 | |
500 mg | In stock | $ 1,550.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 118.00 |
Description | LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
Targets&IC50 | TGF-β receptor type 1 (ALK5):38.2 nM (IC50) |
In vitro | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells. LY3200882 has shown anti-metastatic activity in vitro in migration assays. In in vitro immune suppression assays, LY3200882 has shown the ability to rescue TGFβ1 suppressed or T regulatory cell suppressed na?ve T cell activity and restore proliferation [1]. |
In vivo | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose-dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer) [1]. |
Molecular Weight | 435.52 |
Formula | C24H29N5O3 |
CAS No. | 1898283-02-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 85 mg/mL
You can also refer to dose conversion for different animals. More
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LY3200882 1898283-02-7 Stem Cells TGF-beta/Smad Anti-cancer ALK5 TGFβRI ATP-competitive inhibit immune phosphorylation Transforming growth factor beta receptors anti-metastatic TGF-β Receptor LY-3200882 SMAD serine-threonine Inhibitor LY 3200882 inhibitor