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Leucomethylene blue mesylate
Catalog No. T7003Cas No. 1236208-20-0
Alias TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue Dimesylate
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Leucomethylene blue mesylate
Catalog No. T7003Alias TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue DimesylateCas No. 1236208-20-0
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $50 | In Stock | |
| 10 mg | $68 | In Stock | |
| 25 mg | $123 | In Stock | |
| 50 mg | $203 | In Stock | |
| 100 mg | $349 | In Stock | |
| 200 mg | $526 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
| Targets&IC50 | Tau:0.12 μM (Ki) |
| In vitro | Leucomethylene blue is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of Leucomethylene blue in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM[1]. |
| In vivo | Leucomethylene blue dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66[1]. |
| Alias | TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue Dimesylate |
| Molecular Weight | 477.62 |
| Formula | C16H19N3S·2CH4O3S |
| Cas No. | 1236208-20-0 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 87 mg/mL (182.2 mM) DMSO: 88 mg/mL (184.2 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
TRx-0237Methylene blue leuco baseAβ25-35aggregationTauMethylene blue leuco base MesylateInhibitorLeucomethylene blue MesylateinhibitTRx0237 (LMTX) MesylateLeucomethylene blue mesylateβ-amyloid peptideAmyloid-βDiseaseLeucomethylene BlueLeucomethylene blueTRx0237TRx0237 MesylateTRx 0237Alzheimer'sAbeta
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