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Leucomethylene blue mesylate

Catalog No. T7003 CAS 1236208-20-0

Synonyms: TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue Dimesylate

Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

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Leucomethylene blue mesylate Chemical Structure

Leucomethylene blue mesylate, CAS 1236208-20-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 123.00
50 mg	In stock	$ 203.00
100 mg	In stock	$ 349.00
200 mg	In stock	$ 526.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.99%

Purity: 99.8%

Purity: 97.47%

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Description	Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Targets&IC50	Tau:0.12 μM (Ki)
In vitro	TRx 0237 (LMTX?) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM[1].
In vivo	TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66[1].

Synonyms	TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue Dimesylate
Molecular Weight	477.62
Formula	C16H19N3S·2CH4O3S
CAS No.	1236208-20-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 87 mg/mL (182.2 mM)

DMSO: 88 mg/mL (184.2 mM)

References and Literature

1. Panza F, et al. Expert Opin Pharmacother. 2016, 17(4):457-61. 2. LMTM. THERAPEUTICS overview. 3. Gui W, Xu S, Dang Z, et al. In Vitro and in Vivo Effect of Mapk Signal Transduction Pathway Inhibitors on Echinococcus multilocularis[J]. Journal of Parasitology. 2019 Feb;105(1):146-154. 4. Liu Z, Wang F, Tang M, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A (1) receptor[J]. International journal of molecular medicine. 2019 Jan;43(1):435-442.

Citations

1. Liu Z, Wang F, Tang M, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. International Journal of Molecular Medicine. 2019, 43(1): 435-442 2. Gui W, Xu S, Dang Z, et al. In Vitro and in Vivo Effect of Mapk Signal Transduction Pathway Inhibitors on Echinococcus multilocularis. Journal of Parasitology. 2019 Feb;105(1):146-154.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Microtubule-Targeted Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Clinical Compound Library Neuronal Signaling Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Leucomethylene blue mesylate 1236208-20-0 Cytoskeletal Signaling Neuroscience Microtubule Associated Beta Amyloid TRx-0237 Methylene blue leuco base Aβ25-35 aggregation Tau Methylene blue leuco base Mesylate Inhibitor TRx0237 mesylate Leucomethylene blue Mesylate inhibit TRx0237 (LMTX) Mesylate β-amyloid peptide Amyloid-β Disease Leucomethylene Blue Leucomethylene blue TRx0237 TRx0237 (LMTX) mesylate TRx0237 Mesylate TRx 0237 Methylene blue leuco base mesylate salt Alzheimer's Leucomethylene Blue Dimesylate Abeta inhibitor

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