Shopping Cart
- Remove All
Your shopping cart is currently empty
FPS-ZM1
🥰Excellent
Catalog No. T3259Cas No. 945714-67-0
FPS-ZM1 is a high-affinity, RAGE-specific inhibitor that obstructs Aβ binding to the V domain of RAGE.
FPS-ZM1
🥰Excellent
Purity: 99.3%
Catalog No. T3259Cas No. 945714-67-0
FPS-ZM1 is a high-affinity, RAGE-specific inhibitor that obstructs Aβ binding to the V domain of RAGE.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $43 | In Stock | |
| 10 mg | $52 | In Stock | |
| 25 mg | $93 | In Stock | |
| 50 mg | $150 | In Stock | |
| 100 mg | $231 | In Stock | |
| 200 mg | $369 | In Stock | |
| 500 mg | $622 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "FPS-ZM1"
Ipriflavone
Cited
Osteofix
T030935212-22-7
Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.
- $42
Size
QTY
CitedRutin
Cited
Rutoside, Quercetin 3-O-rutinoside
T0795153-18-4
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
- $36
Size
QTY
CitedDeferoxamine Mesylate Cited
DFOM, Desferrioxamine B mesylate
T1637138-14-7
Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.
- $31
Size
QTY
CitedTramiprosate
Homotaurine, Alzhemed, 3-Amino-1-propanesulfonic acid
T08833687-18-1
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity.
- $42
Size
QTY
Notoginsenoside R1 Cited
Sanqi glucoside R1, Sanchinoside R1
T296180418-24-2
Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
- $63
Size
QTY
CitedGeniposide
T221224512-63-8
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation.
- $60
Size
QTY
Dihydroergocristine mesylate
DHEC (mesylate)
T1104324730-10-7
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of γ-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.
- $48
Size
QTY
Anle138b
T5447882697-00-9
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
- $77
Size
QTY
BSBM7
T198926968-11-2
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
- $29
Size
QTY
Ginsenoside Re Cited
Sanchinoside Re, Panaxoside Re, Ginsenoside B2, Chikusetsusaponin Ivc
T287252286-59-6
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.
- $43
Size
QTY
CitedPQM130
T125322089415-51-8
PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.
- $38
Size
QTY
Select Batch
Purity:99.3%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | FPS-ZM1 is a high-affinity, RAGE-specific inhibitor that obstructs Aβ binding to the V domain of RAGE. |
| Targets&IC50 | RAGE:25 nM. (Ki) |
| In vitro | FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD[1]. |
| In vivo | FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice[1]. |
| Kinase Assay | Human sRAGE is immobilized (10 μg/mL) overnight at 4°C in 96-well microtiter plates and blocked with 3% bovine serum albumin. 125I-labeled Aβ40, HMGB1, or S100B at 5 nM in the absence and presence of various concentrations of FPS2 or FPS-ZM1 (10 to 1,000 nM) is added to the wells containing immobilized sRAGE and incubated for 1 hour at room temperature in PBS. Wells are washed with cold PBS to remove unbound radiolabeled ligands, and the radioactivity is analyzed[1]. |
| Cell Research | CHO cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity was determined using the WST-8 Assay Kit. (Only for Reference) |
| Molecular Weight | 327.85 |
| Formula | C20H22ClNO |
| Cas No. | 945714-67-0 |
| Smiles | Clc1ccc(cc1)C(=O)N(Cc1ccccc1)C1CCCCC1 |
| Relative Density. | 1.18 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (50.84 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy FPS-ZM1 | purchase FPS-ZM1 | FPS-ZM1 cost | order FPS-ZM1 | FPS-ZM1 chemical structure | FPS-ZM1 in vivo | FPS-ZM1 in vitro | FPS-ZM1 formula | FPS-ZM1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.