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Lidocaine

Catalog No. T0468 CAS 137-58-6

Synonyms: Lignocaine, Alphacaine, Xylocaine

Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.

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Lidocaine, CAS 137-58-6

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500 mg	In stock	$ 45.00

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Purity: 99.74%

Purity: 98.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.
Targets&IC50	H1 receptor:>32 μM

Synonyms	Lignocaine, Alphacaine, Xylocaine
Molecular Weight	234.34
Formula	C14H22N2O
CAS No.	137-58-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200.6 mM

H2O: 21.34mM

References and Literature

1. Sheets PL, et al. J Physiol. 2007 Jun 15;581(Pt 3):1019-31.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library GPCR Compound Library Inhibitor Library Kinase Inhibitor Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library EMA Approved Drug Library FDA-Approved Kinase Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lidocaine 137-58-6 Apoptosis GPCR/G Protein Immunology/Inflammation MAPK Membrane transporter/Ion channel Neuroscience NF-Κb Sodium Channel MEK Histamine Receptor ERK NF-κB Extracellular signal regulated kinases Mitogen-activated protein kinase kinase Nuclear factor-kappaB Lignocaine Nuclear factor-κB inhibit Alphacaine Xylocaine MAP2K MAPKK Inhibitor Na channels Na+ channels inhibitor

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