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Liothyronine

Catalog No. T1653 CAS 6893-02-3

Synonyms: Tresitope, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Triiodothyronine, L-3,3',5-Triiodothyronine, 3,3',5-Triiodo-L-thyronine, Lyothyronine

Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.

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Liothyronine, CAS 6893-02-3

Pack Size	Availability	Price/USD
50 mg	In stock	$ 36.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 71.00
500 mg	In stock	$ 119.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.28%

Purity: 98.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
In vitro	Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells. High liothyronine levels induces a low TRalpha1:TRalpha2 ratio which can protect the cell from excessive triiodothyronine-induced gene expression[1].

Synonyms	Tresitope, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Triiodothyronine, L-3,3',5-Triiodothyronine, 3,3',5-Triiodo-L-thyronine, Lyothyronine
Molecular Weight	650.97
Formula	C15H12I3NO4
CAS No.	6893-02-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(139.8 mM)

References and Literature

1. Timmer DC, et al. Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA. J Endocrinol. 2003 Nov;179(2):217-25.

Citations

1. Wang Q, Jin F, Zhang J, et al. Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts. In Vitro Cellular & Developmental Biology-Animal. 2021: 1-9. 2. Dou X, Huo T, Liu Y, et al.Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.European Journal of Medicinal Chemistry.2024: 116323.

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Drug Repurposing Compound Library Human Endogenous Metabolite Compound Library Plus Anti-Cardiovascular Disease Compound Library FDA-Approved Drug Library Bioactive Compound Library Natural Product Library for HTS Human Metabolite Library Anti-Tumor Natural Product Library Target-Focused Phenotypic Screening Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Liothyronine 6893-02-3 Endocrinology/Hormones Metabolism Thyroid hormone receptor(THR) Endogenous Metabolite Inhibitor Tresitope Thyroid Hormone Receptor O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine inhibit TRα T-3 T 3 thyroid hormone THR Triiodothyronine TRβ L-3,3',5-Triiodothyronine 3,3',5-Triiodo-L-thyronine Lyothyronine inhibitor

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