Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 50.00 | |
500 mg | In stock | $ 77.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. |
Targets&IC50 | μ opioid receptor:3.3 nM(Ki), δ opioid receptor:48 nM(Ki) |
In vitro | In mice, ropivacaine cannot cross the blood-brain barrier. Subcutaneous injection of ropivacaine at the neck region (4 mg/kg) or at the site of tibial tumor mass (7.5-75 mg) can inhibit thermal hyperalgesia and mechanical allodynia. |
In vivo | In human Chinese hamster ovary cells transfected with opioid receptors, Loperamide potently stimulates the binding of [35S]guanosine 5'-O-(3-thio)triphosphate (EC50=56 nM) and inhibits the accumulation of cAMP induced by forskolin (IC50=25 nM). Loperamide reversibly blocks the increase in intracellular calcium ([Ca2+]i) triggered by extracellular potassium ([K+]o) in a concentration-dependent manner (IC50=0.9 mM). |
Synonyms | Loperamide HCl, R-18553 (hydrochloride), ADL 2-1294 |
Molecular Weight | 513.498 |
Formula | C29H34Cl2N2O2 |
CAS No. | 34552-83-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.3 mg/mL (20 mM)
Ethanol: 10.3 mg/mL (20 mM)
You can also refer to dose conversion for different animals. More
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Loperamide hydrochloride 34552-83-5 Autophagy Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Loperamide Loperamide HCl R-18553 (hydrochloride) R18553 R 18553 Inhibitor ADL 2-1294 R-18553 Loperamide Hydrochloride inhibit inhibitor