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Lupiwighteone

Catalog No. TN1891 CAS 104691-86-3

Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.

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Lupiwighteone, CAS 104691-86-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 159.00
5 mg	In stock	$ 397.00
10 mg	In stock	$ 589.00
25 mg	In stock	$ 945.00
50 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 570.00

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Purity: 99.20%

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Description	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
In vitro	This study aimed to examine the antitumor activity of Lupiwighteone, explore its antitumor mechanism in a human prostate carcinoma cell line (DU-145), and evaluate its antiangiogenetic activity in the human umbilical vein endothelial cell line (HUVEC). The results showed that Lupiwighteone could inhibit the growth of DU-145 and HUVEC cells in a concentration-dependent and time-dependent manner by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Flow cytometry analysis indicated that Lupiwighteone could induce cell cycle arrest, cells apoptosis, mitochondrial membrane potential loss, and an increase in intracellular reactive oxygen species of DU-145 cells. Upregulation of Bax, cytochrome c, caspase-3, and PARP-1 protein expressions and downregulation of Bcl-2, procaspase-9, and p-Akt protein expressions were observed by western blot after the treatment of Lupiwighteone. Furthermore, the effects of Lupiwighteone on the cellular behavior of HUVECs were also investigated.
Source	Natural Products > Fabaceae > Glycyrrhiza

Molecular Weight	338.35
Formula	C20H18O5
CAS No.	104691-86-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (177.33 mM)

References and Literature

1. Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells.Anticancer Drugs. 2015 Jul;26(6):599-611.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Breast Cancer Compound Library RO5 Drug-like Natural Product Library Flavonoid Natural Product Library Pyroptosis Compound Library Apoptosis Compound Library Natural Product Library for HTS NO PAINS Compound Library Oxidation-Reduction Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Lupiwighteone 104691-86-3 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Proteases/Proteasome Caspase BCL PARP PI3K antioxidant Inhibitor isoflavone mTOR antimicrobial Akt inhibit 8-prenylgenistein inhibitor

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