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MBM-55

Catalog No. T11960   CAS 2083622-09-5

MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.

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MBM-55 Chemical Structure
MBM-55, CAS 2083622-09-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 187.00
5 mg In stock $ 313.00
10 mg In stock $ 455.00
25 mg In stock $ 697.00
50 mg In stock $ 913.00
100 mg In stock $ 1,230.00
500 mg In stock $ 2,490.00
1 mL * 10 mM (in DMSO) In stock $ 343.00
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Purity: 99.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
Targets&IC50 Aurora A:5300 nM , Chk1:57 nM , DYRK1A:6.5 nM , CDK4:441nM , Abl:20 nM , CDK2:370 nM , Nek2:1 nM , GSK-3β:91 nM , Akt1:608 nM , RSK1:5.4 nM
In vitro MBM-55 (0.5-1 μM; 24 hours) induces G2/M phase arrest and accumulation of cells with >4N content in HCT-116 cells. MBM-55 (0.5-1 μM; 24 hours) causes cell apoptosis in a concentration-dependent manner in HCT-116 cells.MBM-55 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.53, 0.84, 7.13 μM, respectively[1].
In vivo In female BALB/c nu/nu mice bearing HCT-116 xenografts, MBM-55 (20 mg/kg; i.p.) exhibits good antitumor activity and a well-tolerated dose schedule. MBM-55 (1.0 mg/kg; i.v.) shows the CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 2.53 L/kg, 1.72 hours, 495 ng/h/mL and 507 ng/h/mL, respectively[1].
Molecular Weight 498.55
Formula C28H27FN6O2
CAS No. 2083622-09-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (240.70 mM), sonification is recommended.

TargetMolReferences and Literature

1. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library Anti-Breast Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Colorectal Cancer Compound Library Anti-Obesity Compound Library Kinase Inhibitor Library Glycolysis Compound Library

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N-Desmethyl imatinib PP1 KW-2449 CGP77675 Pivanex BCR-ABL-IN-8 GNF-5 Nilotinib monohydrochloride monohydrate

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Keywords

MBM-55 2083622-09-5 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors GSK-3 DYRK Aurora Kinase S6 Kinase Chk Bcr-Abl CDK Akt Inhibitor arrest proliferation antitumor Apoptosis cycle cell selectivity inhibit MBM 55 Nek2 MBM55 inhibitor

 

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