Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 187.00 | |
5 mg | In stock | $ 313.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 697.00 | |
50 mg | In stock | $ 913.00 | |
100 mg | In stock | $ 1,230.00 | |
500 mg | In stock | $ 2,490.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 343.00 |
Description | MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. |
Targets&IC50 | Aurora A:5300 nM , Chk1:57 nM , DYRK1A:6.5 nM , CDK4:441nM , Abl:20 nM , CDK2:370 nM , Nek2:1 nM , GSK-3β:91 nM , Akt1:608 nM , RSK1:5.4 nM |
In vitro | MBM-55 (0.5-1 μM; 24 hours) induces G2/M phase arrest and accumulation of cells with >4N content in HCT-116 cells. MBM-55 (0.5-1 μM; 24 hours) causes cell apoptosis in a concentration-dependent manner in HCT-116 cells.MBM-55 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.53, 0.84, 7.13 μM, respectively[1]. |
In vivo | In female BALB/c nu/nu mice bearing HCT-116 xenografts, MBM-55 (20 mg/kg; i.p.) exhibits good antitumor activity and a well-tolerated dose schedule. MBM-55 (1.0 mg/kg; i.v.) shows the CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 2.53 L/kg, 1.72 hours, 495 ng/h/mL and 507 ng/h/mL, respectively[1]. |
Molecular Weight | 498.55 |
Formula | C28H27FN6O2 |
CAS No. | 2083622-09-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (240.70 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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MBM-55 2083622-09-5 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors GSK-3 DYRK Aurora Kinase S6 Kinase Chk Bcr-Abl CDK Akt Inhibitor arrest proliferation antitumor Apoptosis cycle cell selectivity inhibit MBM 55 Nek2 MBM55 inhibitor