Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 278.00 | |
50 mg | In stock | $ 455.00 | |
100 mg | In stock | $ 672.00 | |
500 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM). |
Targets&IC50 | LYPLA2:144 nM(ki), APT-2:(ki)120 nM |
In vitro | ML349 is an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectively. ML349 also is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML348 and ML349 do not reduce cell viability, but they cause a slight activation of AKT in NRAS mutant cells[1][2][3]. |
Molecular Weight | 454.56 |
Formula | C23H22N2O4S2 |
CAS No. | 890819-86-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (44.00 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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ML349 890819-86-0 Metabolism Others Phospholipase Inhibitor inhibit ML-349 ML 349 inhibitor