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MS417

Catalog No. T16154 CAS 916489-36-6

Synonyms: GTPL7512

MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.

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MS417, CAS 916489-36-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 195.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 513.00

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Purity: 99.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.
Targets&IC50	CBP BRD:32.7 μM, BRD4 BD2:46 nM , BRD4 BD1:30 nM
In vivo	BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-κB, effectively attenuates NF-κB transcriptional activation of proinflammatory genes in kidney cells treated with TNFα or infected by HIV.?MS417 ameliorates inflammation and kidney injury in HIV-1 transgenic mice, an animal model for HIVAN[1].

Synonyms	GTPL7512
Molecular Weight	414.91
Formula	C20H19ClN4O2S
CAS No.	916489-36-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 50 mg/mL (120.51 mM), Sonication is recommended.

References and Literature

1. Zhang G, et al. Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51. 2. Cheng-Ming, Chiang. Phospho-BRD4: transcription plasticity and drug targeting[J]. Drug Discovery Today Technologies, 2016.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Epigenetics Compound Library Anti-Viral Compound Library NO PAINS Compound Library Inhibitor Library Anti-Infection Compound Library Kinase Inhibitor Library Histone Modification Compound Library Reprogramming Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MS417 916489-36-6 Chromatin/Epigenetic Microbiology/Virology Proteases/Proteasome HIV Protease Epigenetic Reader Domain GTPL7512 inhibit HIV GTPL-7512 GTPL 7512 Inhibitor MS-417 MS 417 Human immunodeficiency virus inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.