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MST-312

Catalog No. T41290 CAS 368449-04-1

Synonyms: EGCG, Telomerase, epigallocatechin, gallate, Inhibitor, multiple, tea, MST-312, derivative, cancer, MST 312, inhibit, MST312, myeloma, Telomerase Inhibitor IX

MST-312 is an inhibitor of telomerase and can be used in studies about cancer, such as multiple myeloma.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MST-312, CAS 368449-04-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MST-312 is an inhibitor of telomerase and can be used in studies about cancer, such as multiple myeloma.
In vitro	In U-266 cells, MST-312 (2 μM) upregulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes. MST-312 (2-8 μM) reduces cellular viability in a dose dependent and time-dependent manner. MST-312 (2-8 μM) induces cell apoptosis in a dose-dependent manner[1].

Synonyms	EGCG, Telomerase, epigallocatechin, gallate, Inhibitor, multiple, tea, MST-312, derivative, cancer, MST 312, inhibit, MST312, myeloma, Telomerase Inhibitor IX
Molecular Weight	380.356
Formula	C20H16N2O6
CAS No.	368449-04-1

Storage

Powder: -20°C for 3 years In solvent: -80°C for 2 years

Solubility Information

DMSO: 70 mg/mL (184.04 mM), ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Ameri Z, et al. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down-regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019;228:66-71.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.