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Megestrol acetate

Catalog No. T1284 CAS 595-33-5

Synonyms: SC10363, BDH1298

Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

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Megestrol acetate, CAS 595-33-5

Pack Size	Availability	Price/USD
500 mg	In stock	$ 45.00
1 g	In stock	$ 57.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.
Targets&IC50	HegG2:260 μM(ec50)
In vitro	Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. [1] Megestrol acetate significantly increases the proliferation, migration, and adipogenic differentiation of adipose-derived stem cells (ASCs) in a dose-dependent manner. Megestrol acetate also upregulates genes downstream of glucocorticoid receptor (GR) in ASCs. [2]
In vivo	Megestrol acetate significantly decreases the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-ketotestosterone (11-KT) in male fish. Megestrol acetate exposure significantly downregulates the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. [3] Megestrol acetate produces a progressive deterioration in glucose tolerance, with a significant increase in mean fasting plasma glucose concentrations and decrease in mean plasma glucose clearance rates after 6 months and 12 months of treatment in cats. Megestrol acetate also produces a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation in cats. [4] Megestrol acetate (50 mg/kg/day) for 9 days significantly increases food and water intake compared with untreated controls. Megestrol acetate (50 mg/kg/day) significantly (90-140%) increases in neuropeptide Y concentrations in the arcuate nucleus (where neuropeptide Y is synthesized), in the lateral hypothalamic area (through which arcuate neurones project) and in the medial preoptic area, ventromedial nucleus and dorsomedial nucleus in rats. [5]

Synonyms	SC10363, BDH1298
Molecular Weight	384.51
Formula	C24H32O4
CAS No.	595-33-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 7.7 mg/mL (20 mM)

DMSO: 19.2 mg/mL (50 mM)

References and Literature

1. Kelicen Ugur P, et al. Eur J Pharmacol, 2011, 654(3), 217-225. 2. Sung JH, et al. Stem Cells Transl Med. 2015 Jul;4(7):789-99. 3. Han J, et al. Aquat Toxicol,2014, 150, 66-72. 4. Peterson ME, et al. Res Vet Sci,1987, 42(3), 354-357. 5. McCarthy HD, et al. Eur J Pharmacol,1994, 265(1-2), 99-102.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Autophagy Compound Library Orally Active Compound Library Anti-Viral Compound Library Natural Product Library for HTS Anti-Tumor Natural Product Library

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Keywords

Megestrol acetate 595-33-5 Autophagy Endocrinology/Hormones Microbiology/Virology Others Proteases/Proteasome Glucocorticoid Receptor Estrogen/progestogen Receptor Progesterone Receptor HIV Protease syndrome BDH-1298 cachexia Megestrol SC10363 BDH 1298 ACS Inhibitor inhibit BDH1298 AIDs SC-10363 Anorexia NR3C3 SC 10363 HIV Human immunodeficiency virus BPH Megestrol Acetate inhibitor

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