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N-Desmethyl-Apalutamide

Catalog No. T12146 CAS 1332391-11-3

Synonyms: N-Desmethyl Apalutamide

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

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N-Desmethyl-Apalutamide Chemical Structure

N-Desmethyl-Apalutamide, CAS 1332391-11-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 198.00
5 mg	In stock	$ 455.00
10 mg	In stock	$ 657.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00
1 mL * 10 mM (in DMSO)	In stock	$ 490.00

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Purity: 97.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

Synonyms	N-Desmethyl Apalutamide
Molecular Weight	463.41
Formula	C20H13F4N5O2S
CAS No.	1332391-11-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (107.9 mM)

References and Literature

1. Pérez-Ruixo C, et al. Population Pharmacokinetics of Apalutamide and its Active Metabolite N-Desmethyl-Apalutamide in Healthy and Castration-Resistant Prostate Cancer Subjects. Clin Pharmacokinet. 2019 Aug 20. 2. Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)30133 3. May MB, et al. Apalutamide: A new agent in the management of prostate cancer. J Oncol Pharm Pract. 2019 Dec;25(8):1968-1978.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Transcription Factor-Targeted Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Metabolism Compound Library Endocrinology-Hormone Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Desmethyl-Apalutamide 1332391-11-3 Endocrinology/Hormones Metabolism Androgen Receptor P450 CYP3A4 N-Desmethyl Apalutamide plasma-proteins Inhibitor inhibit Metabolite Cytochrome P450 N Desmethyl Apalutamide pharmacological CYP2B6 NDesmethylApalutamide CYPs CYP2C8 inhibitor

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