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NCB-0846

Catalog No. T4011 CAS 1792999-26-8

Synonyms: NCB 0846

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NCB-0846, CAS 1792999-26-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 447.00
100 mg	In stock	$ 659.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.46%

Purity: 98.97%

Purity: 97.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
Targets&IC50	TNIK:21 nM
In vivo	Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo.

Synonyms	NCB 0846
Molecular Weight	375.42
Formula	C21H21N5O2
CAS No.	1792999-26-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL

References and Literature

1. Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Metabolism Compound Library Anti-Cancer Compound Library Cancer Cell Differentiation Compound Library Neural Regeneration Compound Library Anti-Prostate Cancer Compound Library Kinase Inhibitor Library Orally Active Compound Library Inhibitor Library Anti-Cancer Active Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NCB-0846 1792999-26-8 Cytoskeletal Signaling MAPK Stem Cells Wnt/beta-catenin Wnt MAPK Kinase Kinase Kinase Inhibitor inhibit NCB 0846 MAP4K NCB0846 inhibitor

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