Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 85.00 | |
10 mg | In stock | $ 162.00 | |
25 mg | In stock | $ 369.00 | |
50 mg | In stock | $ 553.00 | |
100 mg | In stock | $ 796.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 88.00 |
Description | NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) . |
Targets&IC50 | SK1:0.42 μM (kd), SK3:0.73 μM (kd), SK2:0.60 μM (kd) |
In vitro | It is found that tested in excised patches, the inhibition by NS8593 (compound 14) decreased as the intracellular [Ca2+] is increased and that NS8593 is equipotent when applied from either the intracellular or the extracellular side of the cell membrane.?A HEK293 cell transiently transfected with hSK3 channels is inhibited by 80% upon application of 100 nM apamin and by 75% after application of 300 nM NS8593. |
In vivo | NS8593 is able to affect firing pattern and firing rate?of dopaminergic neurons in vivo in C57Bl/6 mice[1]. |
Synonyms | NS8593 HCl |
Molecular Weight | 299.8 |
Formula | C17H18ClN3 |
CAS No. | 875755-24-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (266.84 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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