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NS8593 hydrochloride

Catalog No. T12256 CAS 875755-24-1

Synonyms: NS8593 HCl

NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .

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NS8593 hydrochloride, CAS 875755-24-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 85.00
10 mg	In stock	$ 162.00
25 mg	In stock	$ 369.00
50 mg	In stock	$ 553.00
100 mg	In stock	$ 796.00
1 mL * 10 mM (in DMSO)	In stock	$ 88.00

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Purity: 99.83%

Biological Description

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Description	NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
Targets&IC50	SK1:0.42 μM (kd), SK3:0.73 μM (kd), SK2:0.60 μM (kd)
In vitro	It is found that tested in excised patches, the inhibition by NS8593 (compound 14) decreased as the intracellular [Ca2+] is increased and that NS8593 is equipotent when applied from either the intracellular or the extracellular side of the cell membrane.?A HEK293 cell transiently transfected with hSK3 channels is inhibited by 80% upon application of 100 nM apamin and by 75% after application of 300 nM NS8593.
In vivo	NS8593 is able to affect firing pattern and firing rate?of dopaminergic neurons in vivo in C57Bl/6 mice[1].

Synonyms	NS8593 HCl
Molecular Weight	299.8
Formula	C17H18ClN3
CAS No.	875755-24-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (266.84 mM), Sonification is recommended.

References and Literature

1. Sørensen US, et al. Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem. 2008 Dec 11;51(23):7625-34. 2. Strøbaek D, et al. Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Mol Pharmacol. 2006 Nov;70(5):1771-82.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Potassium Channel Blocker Library Ion Channel Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NS8593 hydrochloride 875755-24-1 Membrane transporter/Ion channel Potassium Channel NS8593 HCl inhibit NS8593 neurological Ca2+ NS 8593 Hydrochloride Inhibitor hIK SK1 SK2 KcsA NS-8593 Hydrochloride NS-8593 SK3 hBK NS8593 Hydrochloride neurons NS-8593 hydrochloride dopaminergic NS 8593 channel inhibitor

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