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Naftopidil hydrochloride
Catalog No. T9220Cas No. 1164469-60-6
Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-
Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
Naftopidil hydrochloride
Catalog No. T9220Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-Cas No. 1164469-60-6
Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $119 | In Stock | |
| 25 mg | $213 | In Stock | |
| 50 mg | $320 | In Stock | |
| 100 mg | $461 | In Stock | |
| 200 mg | $645 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.50%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects. |
| Targets&IC50 | α1D-adrenoceptor:1.2 nM, α1A-adrenoceptor (human):3.7 nM, α1B-adrenoceptor:20 nM |
| In vitro | Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice[1]. |
| In vivo | Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells[2]. |
| Alias | KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3- |
| Molecular Weight | 428.95 |
| Formula | C24H29ClN2O3 |
| Cas No. | 1164469-60-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (139.88 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
BM-15275BM15275canineprostaticKT611 HydrochlorideNaftopidilprostateKT-611 HydrochloridehyperplasiainhibitBM-15275 HydrochlorideKT 611 HydrochlorideInhibitorNaftopidil hydrochlorideKT-611Adrenergic ReceptorBM 15275 HydrochlorideKT611Naftopidil HydrochlorideKT 611pressureBM15275 HydrochlorideBM 15275Beta Receptor
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