Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 42.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 343.00 | |
100 mg | In stock | $ 587.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively. |
Targets&IC50 | Axl:<1 nM (cell free), c-Met:6.7 nM (cell free), VEGFR2:1.9 nM (cell free) |
In vitro | In cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively. |
In vivo | In the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. |
Synonyms | CT-053, CT053PTSA |
Molecular Weight | 556.58 |
Formula | C31H29FN4O5 |
CAS No. | 1394820-69-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (26.95 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ningetinib 1394820-69-9 Angiogenesis Tyrosine Kinase/Adaptors VEGFR c-Met/HGFR TAM Receptor CT053 Vascular endothelial growth factor receptor inhibit CT-053 Mer Tyro3 CT053PTSA Axl CT 053 Inhibitor inhibitor