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Ningetinib Tosylate

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Purity:99.77%

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COA HPLC HNMR

Ningetinib Tosylate

Catalog No. TQ0041Cas No. 1394820-77-9

Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.

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Pack Size	Price	Availability
2 mg	$42	In Stock
5 mg	$68	In Stock
10 mg	$97	In Stock
25 mg	$189	In Stock
50 mg	$347	In Stock
100 mg	$597	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Product Introduction

Bioactivity

Description	Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
Targets&IC50	c-Met:6.7 nM (cell free), VEGFR2:1.9 nM (cell free), Axl:<1 nM (cell free)
In vitro	In cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively.
In vivo	In the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues.

Chemical Properties

Molecular Weight	728.79
Formula	C38H37FN4O8S
Cas No.	1394820-77-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 8 mg/mL (10.98 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3721 mL	6.8607 mL	13.7214 mL	68.6069 mL
5 mM	0.2744 mL	1.3721 mL	2.7443 mL	13.7214 mL
10 mM	0.1372 mL	0.6861 mL	1.3721 mL	6.8607 mL

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