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Ningetinib Tosylate

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Catalog No. TQ0041Cas No. 1394820-77-9

Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.

Ningetinib Tosylate

Ningetinib Tosylate

🥰Excellent
Purity: 99.93%
Catalog No. TQ0041Cas No. 1394820-77-9
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
Pack SizePriceAvailabilityQuantity
5 mg38 €In Stock
10 mg55 €In Stock
25 mg107 €In Stock
50 mg197 €In Stock
100 mg362 €In Stock
1 mL x 10 mM (in DMSO)61 €In Stock
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Purity:99.93%
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Product Introduction

Bioactivity
Description
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
Targets&IC50
VEGFR2:1.9 nM (cell free), Axl:<1 nM (cell free), c-Met:6.7 nM (cell free)
In vitro
In cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively.
In vivo
In the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues.
Chemical Properties
Molecular Weight728.79
FormulaC38H37FN4O8S
Cas No.1394820-77-9
SmilesCc1ccc(cc1)S(O)(=O)=O.Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 8 mg/mL (10.98 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3721 mL6.8607 mL13.7214 mL68.6069 mL
5 mM0.2744 mL1.3721 mL2.7443 mL13.7214 mL
10 mM0.1372 mL0.6861 mL1.3721 mL6.8607 mL

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