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Catalog No. T3530   CAS 686344-29-6
Synonyms: CP-945598

Otenabant has been investigated for the treatment of Obesity.

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Otenabant, CAS 686344-29-6
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Otenabant has been investigated for the treatment of Obesity.
Targets&IC50 cannabinoid:0.7 nM(Ki)
In vitro Otenabant HCl has a low Ki affinity for human CB2 receptors of 7.6 μM[1]. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration[2].
In vivo Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient which suggests a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle-adjusted weight loss in a 10-day weight loss study in diet-induced obese mice[1]. Otenabant HCl reverses four cannabinoid agonist-mediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation[2].
Synonyms CP-945598
Molecular Weight 510.42
Formula C25H25Cl2N7O
CAS No. 686344-29-6


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: <10 mg/mL (19.59 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. John R. Hadcock, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications, 2010; 394;366-371. 2. Griffith DA, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009 ;5


1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box


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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Otenabant 686344-29-6 GPCR/G Protein Cannabinoid Receptor inhibit CP 945598 CP-945598 Inhibitor CP945598 inhibitor