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Oxaprozin

Catalog No. T0708   CAS 21256-18-8
Synonyms: Oxaprozinum, Wy21743

Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.

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Oxaprozin Chemical Structure
Oxaprozin, CAS 21256-18-8
Pack Size Availability Price/USD Quantity
25 mg In stock $ 45.00
50 mg In stock $ 68.00
100 mg In stock $ 97.00
200 mg In stock $ 158.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.02%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.
Targets&IC50 COX-1:2.2 μM, COX-2:36 μM
Kinase Assay 9L cells are treated with drug for the times indicated in each experiment. Floating and attached cells are collected, pooled, resuspended in lysis buffer (10 mM HEPES buffer, pH 7.4, containing 2 mM EDTA, 0.1% CHAPS detergent, 5 mM DTT, 350 ng/mL phenylmethylsulfonyl fluoride, 10 ng/mL pepstatin A, 10 ng/mL aprotinin, and 20 ng/mL leupeptin) and lysed by three freeze-thaw cycles (alternating between a dry ice isopropanol bath and a 37°C water bath). Lysates are spun in a bench top centrifuge at full speed for 15 min and the supernatant (cell extract) fraction transferred to a new tube. Cell extracts (20 μL) are assayed for caspase 9, caspase 8, and caspase 3 activity by incubation at 37°C for either 1 h (caspase 3) or 3 h (caspase 9 and caspase 8) in 500 μL of reaction buffer (10 mM HEPES, pH 7.4, 2 mM EDTA, 0.1% CHAPS, and 5 mM DTT) containing 50 μM caspase form-selective substrate: Ac-LETD-AFC for caspase 8; Ac-LEHD-AFC for caspase 9; and Ac-DEVD-AMC for caspase 3. Background activity is determined for each sample as follows. Cell extracts are preincubated for 15 min at room temperature, with or without caspase form-selective inhibitor: 1 μM z-LETD-FMK for caspase 8, 1 μM z-LEHD-FMK for caspase 9, and 5 μL of Casputin for caspase 3. Caspase activity measured in the absence of inhibitor is divided by the background caspase activity measured in the presence of inhibitor. A value of 1 is subtracted from each measured activity, such that a caspase activity of 0 corresponds to no increase in the specific caspase activity with drug treatment. Fluorescence of the caspase product (excitation at 395 nm and emission at 525 nm for AFC substrates, and excitation at 380 nm and emission at 460 nm for the AMC substrate) is measured using a Shimadzu model RF-1501 spectrofluorophotometer and the manufacturer's PC-1501 software package.
Synonyms Oxaprozinum, Wy21743
Molecular Weight 293.32
Formula C18H15NO3
CAS No. 21256-18-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 26 mg/mL (88.6 mM)

DMSO: 55 mg/mL (187.5 mM)

TargetMolReferences and Literature

1. Kean WF, et al. Curr Med Res Opin, 2004, 20(8), 1275-1277.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Orally Active Compound Library FDA-Approved Drug Library Neuronal Signaling Compound Library Anti-Ovarian Cancer Compound Library Antidepressant Compound Library Anti-Liver Cancer Compound Library

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Keywords

Oxaprozin 21256-18-8 Immunology/Inflammation Neuroscience NF-Κb NF-κB COX anti-inflammatory IκB kinase PKB I kappa B kinase inhibit Nuclear factor-kappaB Cyclooxygenase IKK Akt Protein kinase B Nuclear factor-κB Wy 21743 Inhibitor Wy-21743 Oxaprozinum Apoptosis NSAID Wy21743 inhibitor

 

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