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PAR-4 Agonist Peptide, amide TFA
Catalog No. TP1065Cas No. 1228078-65-6
Alias PAR-4-AP (TFA), AY-NH2 (TFA)
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4) that does not affect PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist.
PAR-4 Agonist Peptide, amide TFA
Catalog No. TP1065Alias PAR-4-AP (TFA), AY-NH2 (TFA)Cas No. 1228078-65-6
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4) that does not affect PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $47 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $247 | In Stock | |
| 25 mg | $418 | In Stock | |
| 50 mg | $596 | In Stock | |
| 100 mg | $863 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $235 | In Stock |
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Atopaxar
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Vorapaxar
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AY 77
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- $686
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PAR-2 Activating Peptide acetate
SLIGRL-NH2 acetate, Protease-Activated Receptor-2 Activating Peptide acetate, PAR-2 Activating Peptide acetate(171436-38-7 free base)
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FSLLRY-NH2 TFA(245329-02-6 free base)
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FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
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LRGILS-NH2 acetate
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VKGILS-NH2 Acetate
VKGILS-NH2 Acetate (942413-05-0 Free base)
T21699L
VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4) that does not affect PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist. |
| In vivo | SCID mice demonstrate a markedly enhanced abdominal response to colorectal distension (CRD), with distension levels ranging from 0.04 to 0.1 mL amplifying the intensity of the EMG response from 384% to 132%, respectively, as compared to BALB/cBy controls (P<0.01; P<0.01; P<0.01; P<0.001). Activation of PAR-4 significantly mitigates this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1]. |
| Alias | PAR-4-AP (TFA), AY-NH2 (TFA) |
| Molecular Weight | 794.82 |
| Formula | C36H49F3N8O9 |
| Cas No. | 1228078-65-6 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (125.81 mM), Sonication is recommended. DMSO: 250 mg/mL (314.54 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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