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PAR-4 Agonist Peptide, amide TFA

Catalog No. TP1065 CAS 1228078-65-6

Synonyms: PAR-4-AP (TFA), AY-NH2 (TFA)

PAR-4 Agonist Peptide, amide TFA is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

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PAR-4 Agonist Peptide, amide TFA, CAS 1228078-65-6

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	PAR-4 Agonist Peptide, amide TFA is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
In vivo	SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001) when compared with their BALB/cBy controls. PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].

Synonyms	PAR-4-AP (TFA), AY-NH2 (TFA)
Molecular Weight	794.83
Formula	C36H49F3N8O9
CAS No.	1228078-65-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 100 mg/mL (125.81 mM), Need ultrasonic

DMSO: 250 mg/mL (314.54 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Neuronal Signaling Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

SLIGRL-NH2 TRAP-6 PAR-4 Agonist Peptide, amide acetate PAR-4 Agonist Peptide, amide TFLLR-NH2 Thrombin Receptor Activator for Peptide 5 (TRAP-5) Protease-Activated Receptor-4 AC-264613

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

PAR-4 Agonist Peptide, amide TFA 1228078-65-6 G蛋白偶联受体 Protease-activated Receptor Thrombin receptors PAR4 Agonist Peptide, amide TFA Protease Activated Receptor (PAR) inhibit AY-NH2 PAR-4 Agonist Peptide, amide Inhibitor PAR 4 Agonist Peptide, amide TFA PAR-4-AP (TFA) AY-NH2 (TFA) inhibitor

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