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PD-089828

Catalog No. T8976 CAS 179343-17-0

Synonyms: EGFR, ATP, nonselective, PD 089828, PDGFR, autophosphorylation, PD089828, HER1, Epidermal growth factor receptor, ErbB-1, phosphorylation, vascular, antiproliferative, smooth, antimigratory, competitive, Inhibitor, Platelet-derived growth factor receptor, PD-089828, Src, muscle, cells, FGFR, inhibit, Fibroblast growth factor receptor

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PD-089828, CAS 179343-17-0

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Purity: 98%

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Storage & Solubility Information

Description	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
Targets&IC50	PDGFRβ:1.76 µM , FGFR1:0.15 µM , EGFR:5.47 µM
In vitro	PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects.?The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist.

Synonyms	EGFR, ATP, nonselective, PD 089828, PDGFR, autophosphorylation, PD089828, HER1, Epidermal growth factor receptor, ErbB-1, phosphorylation, vascular, antiproliferative, smooth, antimigratory, competitive, Inhibitor, Platelet-derived growth factor receptor, PD-089828, Src, muscle, cells, FGFR, inhibit, Fibroblast growth factor receptor
Molecular Weight	405.28
Formula	C18H18Cl2N6O
CAS No.	179343-17-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2.5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Dahring TK, et al. Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Anti-Breast Cancer Compound Library Angiogenesis related Compound Library JAK-STAT Compound Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

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