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PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $42 | In Stock | |
2 mg | $58 | In Stock | |
5 mg | $105 | In Stock | |
10 mg | $166 | In Stock | |
25 mg | $342 | In Stock | |
50 mg | $547 | In Stock | |
100 mg | $789 | In Stock | |
1 mL x 10 mM (in DMSO) | $105 | In Stock |
Description | PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively. |
Targets&IC50 | MAP4K4:3.7 nM |
In vitro | Treatment with PF-06260933 significantly enhances the resistance of human aortic endothelial cells (EC) to TNF-α-induced increases in endothelial permeability in vitro. |
In vivo | Treatment with PF-06260933 does not modify plasma lipid content in a mouse model, yet it leads to decreased glucose levels, mirroring outcomes seen in whole-body-inducible Map4k4 knockout animals. Moreover, PF-06260933 administration results in either the attenuation of plaque progression or promotion of plaque regression in this model (46.0% versus 25.5%), alongside reductions in both plasma glucose and lipid content. |
Alias | PF-6260933, PF6260933, PF 6260933 |
Molecular Weight | 296.75 |
Formula | C16H13ClN4 |
Cas No. | 1811510-56-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (168.49 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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