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PF-06260933

Catalog No. T4221Cas No. 1811510-56-1
Alias PF-6260933, PF6260933, PF 6260933

PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.

PF-06260933

PF-06260933

Purity: 99.97%
Catalog No. T4221Alias PF-6260933, PF6260933, PF 6260933Cas No. 1811510-56-1
PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$42In Stock
2 mg$58In Stock
5 mg$105In Stock
10 mg$166In Stock
25 mg$342In Stock
50 mg$547In Stock
100 mg$789In Stock
1 mL x 10 mM (in DMSO)$105In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
Targets&IC50
MAP4K4:3.7 nM
In vitro
Treatment with PF-06260933 significantly enhances the resistance of human aortic endothelial cells (EC) to TNF-α-induced increases in endothelial permeability in vitro.
In vivo
Treatment with PF-06260933 does not modify plasma lipid content in a mouse model, yet it leads to decreased glucose levels, mirroring outcomes seen in whole-body-inducible Map4k4 knockout animals. Moreover, PF-06260933 administration results in either the attenuation of plaque progression or promotion of plaque regression in this model (46.0% versus 25.5%), alongside reductions in both plasma glucose and lipid content.
AliasPF-6260933, PF6260933, PF 6260933
Chemical Properties
Molecular Weight296.75
FormulaC16H13ClN4
Cas No.1811510-56-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (168.49 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3698 mL16.8492 mL33.6984 mL168.4920 mL
5 mM0.6740 mL3.3698 mL6.7397 mL33.6984 mL
10 mM0.3370 mL1.6849 mL3.3698 mL16.8492 mL
20 mM0.1685 mL0.8425 mL1.6849 mL8.4246 mL
50 mM0.0674 mL0.3370 mL0.6740 mL3.3698 mL
100 mM0.0337 mL0.1685 mL0.3370 mL1.6849 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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