Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

PFI-2 hydrochloride

Catalog No. T4583Cas No. 1627607-87-7
Alias PFI-2 HCl, (R)-PFI-2 hydrochloride

PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.

PFI-2 hydrochloride

PFI-2 hydrochloride

Purity: 99.91%
Catalog No. T4583Alias PFI-2 HCl, (R)-PFI-2 hydrochlorideCas No. 1627607-87-7
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
2 mg$47In Stock
5 mg$77In Stock
10 mg$119In Stock
25 mg$223In Stock
50 mg$397In Stock
100 mg$582In Stock
500 mg$1,230In Stock
1 mL x 10 mM (in DMSO)$130In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "PFI-2 hydrochloride"

Select Batch
Purity:99.91%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.
Targets&IC50
SETD7:2 nM
In vitro
(R)-PFI-2 is highly selective (>1,000-fold) for SETD7, over a panel of 18 other human protein methyltransferases and DNMT1, and was shown to be inactive against 134 additional ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). (R)-PFI-2 binds to SETD7 only in the presence of SAM. PFI-766, a biotinylated variant of (R)-PFI-2 that retains the ability to bind and inhibit SETD7 (IC50 110 ± 26 nM in our in vitro enzymatic assay).
AliasPFI-2 HCl, (R)-PFI-2 hydrochloride
Chemical Properties
Molecular Weight535.98
FormulaC23H26ClF4N3O3S
Cas No.1627607-87-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (102.62 mM)
Ethanol: 10 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8657 mL9.3287 mL18.6574 mL93.2871 mL
5 mM0.3731 mL1.8657 mL3.7315 mL18.6574 mL
10 mM0.1866 mL0.9329 mL1.8657 mL9.3287 mL
20 mM0.0933 mL0.4664 mL0.9329 mL4.6644 mL
50 mM0.0373 mL0.1866 mL0.3731 mL1.8657 mL
100 mM0.0187 mL0.0933 mL0.1866 mL0.9329 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy PFI-2 hydrochloride | purchase PFI-2 hydrochloride | PFI-2 hydrochloride cost | order PFI-2 hydrochloride | PFI-2 hydrochloride chemical structure | PFI-2 hydrochloride in vitro | PFI-2 hydrochloride formula | PFI-2 hydrochloride molecular weight