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Peretinoin

Catalog No. TQ0064   CAS 81485-25-8
Synonyms: NIK333

Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.

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Peretinoin Chemical Structure
Peretinoin, CAS 81485-25-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 80.00
10 mg In stock $ 128.00
25 mg In stock $ 243.00
50 mg In stock $ 423.00
100 mg In stock $ 629.00
500 mg In stock $ 1,350.00
1 mL * 10 mM (in DMSO) In stock $ 89.00
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Purity: 99.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
In vitro Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment [1]. Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with an EC50 of 9 μM [3].
Cell Research Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line. Concentration: 5 μM. Incubation Time: 24 hours [2]
Synonyms NIK333
Molecular Weight 302.45
Formula C20H30O2
CAS No. 81485-25-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (165.32 mM), sonification is recommended.

TargetMolReferences and Literature

1. Honda M, et al. Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191. 2. Okada H, et al. Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Oncotarget. 2017 Jun 20;8(25):39978-39993. 3. Funaki M, et al. Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. Sci Rep. 2017 Dec 5;7(1):16978.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Lipid Metabolism Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Orally Active Compound Library Bioactive Compounds Library Max

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Keywords

Peretinoin 81485-25-8 Autophagy GPCR/G Protein Metabolism Microbiology/Virology Proteases/Proteasome Retinoid Receptor HCV Protease S1P Receptor inhibit Retinoic acid receptors SphK Retinoid X receptors HCV Inhibitor NIK 333 Sphingosine kinase NIK-333 Hepatitis C virus RAR/RXR NIK333 inhibitor

 

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