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GPCR/G Protein PKA Piceatannol

Piceatannol

Catalog No. T0610   CAS 10083-24-6
Synonyms: trans-Piceatannol, Astringenin
Purity 98.66% Datasheet

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.

Piceatannol, CAS 10083-24-6
Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 68.00
25 mg In stock 130.00
50 mg In stock 189.00
100 mg In stock 267.00
200 mg In stock 480.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
Targets&IC50 cAK :ic50 3μM,   MLCK :ic50 12μM,   PKC :ic50 8μM,  
Kinase Assay In Vitro Protein-tyrosine Kinase Assays: Recombinant Syk is expressed in baculovirus-infected St9 cells. Assays of recombinant Syk activity are carried out using angiotensin I peptide as substrate. The enzyme activities of recombinant Syk are measured by phosphorylation of angiotensin I peptide in the presence of various concentrations of Piceatannol.
Cell Research
Cells are exposed to increasing concentrations of Piceatannol. For the determination of cell proliferation, cells are assayed at 72 hours by trypan blue exclusion using a hemocytometer. After 1 week, colonies are stained with 1.25% crystal violet and quantified by measuring the absorbance at 595 nm. (Only for Reference)
Cell lines: LNCaP, DU145, and PC-3
Animal Research
Animal Model: FeBALB/c mice with dextran sulfate sodium (DSS)-induced colitis
Synonyms trans-Piceatannol, Astringenin
Purity 98.00%
Appearance solid
Molecular Weight 244.24
Formula C14H12O4
CAS No. 10083-24-6

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 24.4 mg/mL (100 mM)

Ethanol: 24.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL

Citations

References and Literature
1. Oliver JM, et al. J Biol Chem, 1994, 269(47), 29697-29703. 2. Wang BH, et al. Planta Med, 1998, 64(3), 195-199. 3. Su L, et al. J Biol Chem, 2000, 275(17), 12661-12666. 4. Wieder T, et al. Leukemia, 2001, 15(11), 1735-1742. 5. Ashikawa K, et al. J Immunol, 2002, 169(11), 6490-6497. 6. Fernandez LA, et al. Transplantation, 2002, 74(11), 1609-1617. 7. Kim YH, et al. Int Immunopharmacol, 2008, 8(12), 1695-1702. 8. Choi KH, et al. Cardiovasc Res, 2010, 85(4), 836-844. 9. Minakawa M, et al. Biochem Biophys Res Commun, 2012, 422(3), 469-475. 10. Hsieh TC, et al. ISRN Urol, 2012, 272697.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Apoptosis Compound Library Autophagy Compound Library Tyrosine kinase inhibitor library Selected Plant-sourced Compound Library Kinase Inhibitor Library GPCR Compound Library Anti-cancer Approved drug Library Angiogenesis related Compound Library

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