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Piceatannol

Catalog No. T0610 CAS 10083-24-6

Synonyms: Spleen tyrosine kinase, anticancer, Piceatannol, Autophagy, ALI, iNOS, acute, Inhibitor, inhibit, Syk, Astringenin, Apoptosis, injury, lung, anti-inflammatory, trans-Piceatannol

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.

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Piceatannol, CAS 10083-24-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
Targets&IC50	PKC:8 μM, MLCK:12 μM, cAK:3 μM
Kinase Assay	In Vitro Protein-tyrosine Kinase Assays: Recombinant Syk is expressed in baculovirus-infected St9 cells. Assays of recombinant Syk activity are carried out using angiotensin I peptide as substrate. The enzyme activities of recombinant Syk are measured by phosphorylation of angiotensin I peptide in the presence of various concentrations of Piceatannol.
Cell Research	Cells are exposed to increasing concentrations of Piceatannol. For the determination of cell proliferation, cells are assayed at 72 hours by trypan blue exclusion using a hemocytometer. After 1 week, colonies are stained with 1.25% crystal violet and quantified by measuring the absorbance at 595 nm. (Only for Reference)

Synonyms	Spleen tyrosine kinase, anticancer, Piceatannol, Autophagy, ALI, iNOS, acute, Inhibitor, inhibit, Syk, Astringenin, Apoptosis, injury, lung, anti-inflammatory, trans-Piceatannol
Molecular Weight	244.24
Formula	C14H12O4
CAS No.	10083-24-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 24.4 mg/mL (100 mM)

DMSO: 24.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Oliver JM, et al. J Biol Chem, 1994, 269(47), 29697-29703. 2. Wang BH, et al. Planta Med, 1998, 64(3), 195-199. 3. Su L, et al. J Biol Chem, 2000, 275(17), 12661-12666. 4. Wieder T, et al. Leukemia, 2001, 15(11), 1735-1742. 5. Ashikawa K, et al. J Immunol, 2002, 169(11), 6490-6497.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library GPCR Compound Library Traditional Chinese Medicine Monomer Library Tibetan medicine Compound Library Hematonosis Compound Library Inhibitor Library Polyphenolic Natural Product Library Drug-induced Liver Injury (DILI) Compound Library Natural Product Library for HTS

Related Products

Related compounds with same targets

Salinomycin sodium salt (S)-(−)-Perillyl alcohol CPI-360 Chetomin WYE-132 GSK1904529A LYN-1604 Curzerene

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