Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
Description | Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1. |
Targets&IC50 | PKC:8 μM, MLCK:12 μM, cAK:3 μM |
Kinase Assay | In Vitro Protein-tyrosine Kinase Assays: Recombinant Syk is expressed in baculovirus-infected St9 cells. Assays of recombinant Syk activity are carried out using angiotensin I peptide as substrate. The enzyme activities of recombinant Syk are measured by phosphorylation of angiotensin I peptide in the presence of various concentrations of Piceatannol. |
Cell Research | Cells are exposed to increasing concentrations of Piceatannol. For the determination of cell proliferation, cells are assayed at 72 hours by trypan blue exclusion using a hemocytometer. After 1 week, colonies are stained with 1.25% crystal violet and quantified by measuring the absorbance at 595 nm. (Only for Reference) |
Synonyms | Spleen tyrosine kinase, anticancer, Piceatannol, Autophagy, ALI, iNOS, acute, Inhibitor, inhibit, Syk, Astringenin, Apoptosis, injury, lung, anti-inflammatory, trans-Piceatannol |
Molecular Weight | 244.24 |
Formula | C14H12O4 |
CAS No. | 10083-24-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 24.4 mg/mL (100 mM)
DMSO: 24.4 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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