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Piceatannol

Catalog No. T0610 CAS 10083-24-6

Synonyms: trans-Piceatannol, Astringenin

Purity 98.66% Datasheet

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.

Piceatannol, CAS 10083-24-6

Pack Size	Availability	Price/USD
5 mg	In stock	50.00
10 mg	In stock	68.00
25 mg	In stock	130.00
50 mg	In stock	189.00
100 mg	In stock	267.00
200 mg	In stock	480.00
1 mL * 10 mM (in DMSO)	In stock	50.00

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Purity 98.66%

HNMR HPLC COA Datasheet

Purity 98.00%

HNMR COA Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

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Description	Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
Targets&IC50	cAK :ic50 3μM, MLCK :ic50 12μM, PKC :ic50 8μM,
Kinase Assay	In Vitro Protein-tyrosine Kinase Assays: Recombinant Syk is expressed in baculovirus-infected St9 cells. Assays of recombinant Syk activity are carried out using angiotensin I peptide as substrate. The enzyme activities of recombinant Syk are measured by phosphorylation of angiotensin I peptide in the presence of various concentrations of Piceatannol.
Cell Research	Cells are exposed to increasing concentrations of Piceatannol. For the determination of cell proliferation, cells are assayed at 72 hours by trypan blue exclusion using a hemocytometer. After 1 week, colonies are stained with 1.25% crystal violet and quantified by measuring the absorbance at 595 nm. (Only for Reference) Cell lines: LNCaP, DU145, and PC-3
Animal Research	Animal Model: FeBALB/c mice with dextran sulfate sodium (DSS)-induced colitis

Synonyms	trans-Piceatannol, Astringenin
Purity	98.00%
Appearance	solid
Molecular Weight	244.24
Formula	C14H12O4
CAS No.	10083-24-6

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 24.4 mg/mL (100 mM)

Ethanol: 24.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL

Citations

References and Literature

1. Oliver JM, et al. J Biol Chem, 1994, 269(47), 29697-29703. 2. Wang BH, et al. Planta Med, 1998, 64(3), 195-199. 3. Su L, et al. J Biol Chem, 2000, 275(17), 12661-12666. 4. Wieder T, et al. Leukemia, 2001, 15(11), 1735-1742. 5. Ashikawa K, et al. J Immunol, 2002, 169(11), 6490-6497. 6. Fernandez LA, et al. Transplantation, 2002, 74(11), 1609-1617. 7. Kim YH, et al. Int Immunopharmacol, 2008, 8(12), 1695-1702. 8. Choi KH, et al. Cardiovasc Res, 2010, 85(4), 836-844. 9. Minakawa M, et al. Biochem Biophys Res Commun, 2012, 422(3), 469-475. 10. Hsieh TC, et al. ISRN Urol, 2012, 272697.

Related Compound Libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Apoptosis Compound Library Autophagy Compound Library Tyrosine kinase inhibitor library Selected Plant-sourced Compound Library Kinase Inhibitor Library GPCR Compound Library Anti-cancer Approved drug Library Angiogenesis related Compound Library

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