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Polygalacin D

Catalog No. TN2091   CAS 66663-91-0

Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2).

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Polygalacin D Chemical Structure
Polygalacin D, CAS 66663-91-0
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5 mg Inquiry $ 360.00
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25 mg Inquiry $ 910.00
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100 mg Inquiry $ 2,043.00
1 mL * 10 mM (in DMSO) Inquiry $ 653.00
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Purity: 99.77%
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Biological Description
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Storage & Solubility Information
Description Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2).
In vitro In this study, we investigated the effects of seven platycodin saponins on the activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase II (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. We found that 2'-O-acetyl Polygalacin D (S1), platycodin A (S2), platycodin D (S3), and Polygalacin D (S6) inhibited LPS-induced NO production in a concentration-dependent manner. Furthermore, these compounds inhibited the expression of LPS-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and could suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2). Treatment with these compounds of RAW 264.7 cells transfected with a reporter construct indicated a reduced level of LPS-induced nuclear factor-kappaB (NF-kappaB) activity and effectively lowered NF-kappaB binding as measured by electrophoretic mobility shift assay (EMSA). The suppression of NF-kappaB activation appears to occur through the prevention of inhibitor kappaB (IkappaB) degradation. In vivo, platycodin saponin mixture (PS) and S3 protected mice from the lethal effects of LPS. The 89% lethality induced by LPS/galactosamine was reduced to 60% and 50% when PS and S3, respectively, were administered simultaneously with LPS[1]
Source
Molecular Weight 1209.4
Formula C57H92O27
CAS No. 66663-91-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (45.48 mM)

TargetMolReferences and Literature

1. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci., 2005, 76(20):2315-28.

TargetMolCitations

1. Lee S J, Kim H W, Lee S, et al. Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS. Molecules. 2022, 27(1): 107.

Related compound libraries

This product is contained In the following compound libraries:
Antiparasitic Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Chinese Pharmacopoeia Natural Product Library Food as Medicine Compound Library Traditional Mongolian Medicine Compound Library Anti-Tumor Natural Product Library

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Keywords

Polygalacin D 66663-91-0 Apoptosis IAP Inhibitor inhibit inhibitor

 

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