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R306465
Catalog No. T21324Cas No. 604769-01-9
Alias R-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199
R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
R306465
Catalog No. T21324Alias R-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199Cas No. 604769-01-9
R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $139 | In Stock | |
| 5 mg | $352 | In Stock | |
| 10 mg | $620 | In Stock | |
| 25 mg | $1,220 | In Stock |
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Purity:99.64%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies. |
| Targets&IC50 | HDAC1:23 nM, HDAC1:3.3 nM |
| In vitro | b>METHODS: A2780 cells were treated with R306465 (0.1, 0.3, 1 μM, 24-48 h), and FACS analysis was performed to analyze whether the antiproliferative effect in A2780 cells was attributed to the induction of cell cycle arrest or cell death. RESULTS: R306465 induced apoptosis of A2780 cells in a concentration-dependent manner and inhibited angiogenesis. [2] |
| In vivo | b>METHODS: R306465 (10-40 mpk, oral) was administered subcutaneously to nude mice bearing A2780, H460, and HCT116 cell models, and tumor growth in nude mice was observed. RESULTS: R306465 inhibited tumor growth in the three nude mouse models. [2] |
| Alias | R-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199 |
| Molecular Weight | 413.45 |
| Formula | C19H19N5O4S |
| Cas No. | 604769-01-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (12.09 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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