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R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $139 | In Stock | |
5 mg | $352 | In Stock | |
10 mg | $620 | In Stock | |
25 mg | $1,220 | In Stock |
Description | R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies. |
Targets&IC50 | HDAC1:23 nM, HDAC1:3.3 nM |
In vitro | b>METHODS: A2780 cells were treated with R306465 (0.1, 0.3, 1 μM, 24-48 h), and FACS analysis was performed to analyze whether the antiproliferative effect in A2780 cells was attributed to the induction of cell cycle arrest or cell death. RESULTS: R306465 induced apoptosis of A2780 cells in a concentration-dependent manner and inhibited angiogenesis. [2] |
In vivo | b>METHODS: R306465 (10-40 mpk, oral) was administered subcutaneously to nude mice bearing A2780, H460, and HCT116 cell models, and tumor growth in nude mice was observed. RESULTS: R306465 inhibited tumor growth in the three nude mouse models. [2] |
Alias | R-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199 |
Molecular Weight | 413.45 |
Formula | C19H19N5O4S |
Cas No. | 604769-01-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (12.09 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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