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R306465

Catalog No. T21324Cas No. 604769-01-9
Alias R-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199

R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.

R306465

R306465

Purity: 99.64%
Catalog No. T21324Alias R-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199Cas No. 604769-01-9
R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
Pack SizePriceAvailabilityQuantity
1 mg$139In Stock
5 mg$352In Stock
10 mg$620In Stock
25 mg$1,220In Stock
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Purity:99.64%
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Product Introduction

Bioactivity
Description
R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
Targets&IC50
HDAC1:23 nM, HDAC1:3.3 nM
In vitro
b>METHODS: A2780 cells were treated with R306465 (0.1, 0.3, 1 μM, 24-48 h), and FACS analysis was performed to analyze whether the antiproliferative effect in A2780 cells was attributed to the induction of cell cycle arrest or cell death.
RESULTS: R306465 induced apoptosis of A2780 cells in a concentration-dependent manner and inhibited angiogenesis. [2]
In vivo
b>METHODS: R306465 (10-40 mpk, oral) was administered subcutaneously to nude mice bearing A2780, H460, and HCT116 cell models, and tumor growth in nude mice was observed.
RESULTS: R306465 inhibited tumor growth in the three nude mouse models. [2]
AliasR-306465, R 306465, JNJ-16241199, JNJ16241199, JNJ 16241199
Chemical Properties
Molecular Weight413.45
FormulaC19H19N5O4S
Cas No.604769-01-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5 mg/mL (12.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4187 mL12.0934 mL24.1867 mL120.9336 mL
5 mM0.4837 mL2.4187 mL4.8373 mL24.1867 mL
10 mM0.2419 mL1.2093 mL2.4187 mL12.0934 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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