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RGB-286638 free base

Catalog No. T2378 CAS 784210-88-4

Synonyms: RGB-286638, inhibit, MAP2K, RGB286638 free base, Glycogen synthase kinase-3, MAPKK, RGB 286638, Glycogen synthase kinase 3, MEK, RGB 286638 free base, Mitogen-activated protein kinase kinase, RGB286638, JAK, GSK-3, Janus kinase, Cyclin dependent kinase, CDK, Inhibitor

RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RGB-286638 free base, CAS 784210-88-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
Targets&IC50	cyclin D1-CDK4:4 nM, cyclin E-CDK3:5 nM, cyclin T1-CDK9:1 nM, cyclin B1-CDK1:2 nM, cyclin E-CDK2:3 nM

Synonyms	RGB-286638, inhibit, MAP2K, RGB286638 free base, Glycogen synthase kinase-3, MAPKK, RGB 286638, Glycogen synthase kinase 3, MEK, RGB 286638 free base, Mitogen-activated protein kinase kinase, RGB286638, JAK, GSK-3, Janus kinase, Cyclin dependent kinase, CDK, Inhibitor
Molecular Weight	545.644
Formula	C29H35N7O4
CAS No.	784210-88-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Cirstea D, et al. Leukemia. 2013 Dec;27(12):2366-75.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Wnt/Hedgehog/Notch Compound Library Cell Cycle Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-COVID-19 Compound Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

Kobophenol A Dehydrodiconiferyl alcohol SB1317 BS-181 Ribociclib hydrochloride CP-10 T025 FMF-04-159-2

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.