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RH1
🥰Excellent
Catalog No. T16740Cas No. 221635-42-3
Alias NSC 697726
RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses.
RH1
🥰Excellent
Purity: 99.15%
Catalog No. T16740Alias NSC 697726Cas No. 221635-42-3
RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $197 | In Stock | |
| 5 mg | $446 | In Stock | |
| 10 mg | $718 | In Stock | |
| 25 mg | $1,450 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Purity:99.15%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RH1 (NSC 697726) is a bioreductive anticancer compound that exhibits dose-dependent biphasic effects in vitro, inducing apoptosis at higher doses and senescence at lower doses. |
| In vitro | RH1 causes apoptosis in NQ16 cells in a time- and concentration-dependent manner. Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 minutes resulted in a significant (p< 0.05) increase in cross-linked DNA [1]. |
| In vivo | RH1 exhibited dose-dependent antitumor activity against NQ16 tumors grown in thymus-free mice. A small dose of RH1 (0.1 mg/kg) also resulted in a significant reduction in tumor size in treated mice compared to controls. Treatment of mice with NQ16 tumors with RH1 (0.4 mg/kg and 0.2 mg/kg) resulted in a significant reduction in tumor size between the treated and control groups as early as 5 days after the end of the treatment period [2]. |
| Alias | NSC 697726 |
| Molecular Weight | 234.25 |
| Formula | C12H14N2O3 |
| Cas No. | 221635-42-3 |
| Smiles | O=C1C(=C(C(=O)C(=C1C)N2CC2)CO)N3CC3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (4.26 mM), Sonication and heating are recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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