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Rabeximod

Catalog No. T34249 CAS 872178-65-9

Synonyms: ROB-803

Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by stimulating TLR2 and TLR4 downstream to block the activation of inflammatory cells, most likely macrophages. Rabeximod effectively reduces brain antigen presentation in mice during anti-inflammatory therapy for traumatic brain injury.

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Rabeximod, CAS 872178-65-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 258.00
5 mg	In stock	$ 642.00
10 mg	In stock	$ 913.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 1,850.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 100%

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Description

In vivo

Rabeximod efficiently prevented arthritis during the time window when TLR2 or TLR4 ligands activate inflammatory macrophages. The effect operated downstream of TLR activation as Rabeximod was highly therapeutic in CAIA enhanced through TLR2 stimuli in TLR4 deficient mice. In addition, it was found that the arthritis ameliorating effect of Rabeximod was time dependent, since inhibition of tumour necrosis factor α production from macrophages in vitro was more pronounced if administered close to stimulation.[1]

Synonyms	ROB-803
Molecular Weight	409.91
Formula	C22H24ClN5O
CAS No.	872178-65-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Hultqvist M, et al. Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells. Ann Rheum Dis. 2010;69(8):1527-1532. 2. Hultqvist M, et al. Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells. Ann Rheum Dis. 2010 Aug;69(8):1527-32. 3. Giusti P, et al. The novel anti-rheumatic compound Rabeximod impairs differentiation and function of human pro-inflammatory dendritic cells and macrophages. Immunobiology. 2011 Jan-Feb;216(1-2):243-50. 4. Hultqvist M, et al. The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders. Ann Rheum Dis. 2009 Jan;68(1):130-5.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Clinical Compound Library Bioactive Compounds Library Max

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Pam3CSK4 TFA (112208-00-1 free base) SM360320 CL075 BBIQ Bropirimine MD2-IN-1 TLR7/8/9-IN-1 TLR3-IN-1

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Keywords

Rabeximod 872178-65-9 Immunology/Inflammation TLR ROB 803 ROB803 ROB-803 inhibitor inhibit

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