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Ramelteon

Catalog No. T1463 CAS 196597-26-9

Synonyms: TAK-375

Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.

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Ramelteon, CAS 196597-26-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 37.00
5 mg	In stock	$ 59.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 138.00
50 mg	In stock	$ 213.00
100 mg	In stock	$ 343.00
500 mg	In stock	$ 539.00
1 mL * 10 mM (in DMSO)	In stock	$ 65.00

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Purity: 99.94%

Purity: 99.22%

Purity: 97.21%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
Targets&IC50	MT2 receptor:112 pM(Ki), MT receptor (chicken):23.1 pM(Ki), MT1 receptor:14 pM(Ki)
Kinase Assay	cDNA encoding the human MT1 gene is introduced into CHO cells. Cells are harvested at confluence in Ca2+ and Mg2+ free Hanks' balanced salt solution containing 5 mM EDTA and collected by centrifugation. Cells are homogenized in ice-cold 50 mM Tris–HCl buffer, washed twice, pelleted, and stored at -30°C until the binding assays are conducted. Test compound and 40 pM 2-[ 125I]melatonin are mixed with the thawed homogenate in a total volume of 1 mL and incubated at 25°C for 150 min. The reaction is terminated by addition of 3 mL of icecold buffer followed by vacuum filtration on a Whatman GF/B. The filter is washed twice and radioactivity is counted by a g-counter[1].

Synonyms	TAK-375
Molecular Weight	259.34
Formula	C16H21NO2
CAS No.	196597-26-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 49 mg/mL (188.9 mM)

DMSO: 49 mg/mL (188.9 mM)

References and Literature

1. Kato K, et al. Neuropharmacology, 2005, 48(2), 301-310. 2. Fisher SP, et al. J Pineal Res, 2008, 45(2), 125-132. 3. Imbesi M, et al. Neuroscience, 2008, 155(4), 1160-1164. 4. Hirai K, et al. J Biol Rhythms, 2005, 20(1), 27-37. 5. Yukuhiro N, et al. Brain Res, 2004, 1027(1-2), 59-66.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library GPCR Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Clinical Compound Library Pediatric Drug Library FDA-Approved & Pharmacopeia Drug Library CNS-Penetrant Compound Library

Related Products

Related compounds with same targets

Tasimelteon Melatonin Luzindole 4-P-PDOT ACH-000143 N-ACETYLTRYPTAMINE Agomelatine 6-Chloromelatonin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ramelteon 196597-26-9 GPCR/G Protein Neuroscience Melatonin Receptor MT Receptor TAK375 rebound insomnia TAK-375 insomnia MT2 withdrawal symptom MT1 inhibit discontinuation Inhibitor next-morning residual effect oral TAK 375 inhibitor

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