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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $47 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $176 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $443 | In Stock | |
1 mL x 10 mM (in DMSO) | $85 | In Stock |
Description | Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM). |
In vitro | GDC-0994 significantly inhibits phospho-p90RSK in tumor cells. |
In vivo | GDC-0994 (p.o.) inhibits intracellular ERK phosphorylation and activation of ERK-mediated signaling pathways, subsequently impeding the proliferation and survival of ERK-dependent tumor cells. In in vitro cancer models, GDC-0994 (p.o.) demonstrates significant single-dose efficacy, including against BRAF and KRAS mutant human xenograft tumors in mice. |
Alias | GDC-0994 |
Molecular Weight | 440.86 |
Formula | C21H18ClFN6O2 |
Cas No. | 1453848-26-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 81 mg/mL (183.7 mM) DMSO: 81 mg/mL (183.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol
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