Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 176.00 | |
50 mg | In stock | $ 297.00 | |
100 mg | In stock | $ 443.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 85.00 |
Description | Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM). |
Targets&IC50 | ERK2:0.3 nM, ERK1:1.1 nM |
In vitro | GDC-0994 (p.o.) inhibits intracellular ERK phosphorylation and activation of ERK-mediated signaling pathways, subsequently impeding the proliferation and survival of ERK-dependent tumor cells. In in vitro cancer models, GDC-0994 (p.o.) demonstrates significant single-dose efficacy, including against BRAF and KRAS mutant human xenograft tumors in mice. |
In vivo | GDC-0994 significantly inhibits phospho-p90RSK in tumor cells. |
Synonyms | GDC-0994 |
Molecular Weight | 440.86 |
Formula | C21H18ClFN6O2 |
CAS No. | 1453848-26-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 81 mg/mL (183.7 mM)
DMSO: 81 mg/mL (183.7 mM)
You can also refer to dose conversion for different animals. More
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Ravoxertinib 1453848-26-4 MAPK ERK GDC0994 inhibit GDC 0994 Extracellular signal regulated kinases GDC-0994 Inhibitor inhibitor