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Ravoxertinib
🥰Excellent
Catalog No. T6511Cas No. 1453848-26-4
Alias GDC-0994
Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM.
Ravoxertinib
🥰Excellent
Purity: 99.87%
Catalog No. T6511Alias GDC-0994Cas No. 1453848-26-4
Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 32 € | In Stock | |
| 2 mg | 44 € | In Stock | |
| 5 mg | 73 € | In Stock | |
| 10 mg | 92 € | In Stock | |
| 25 mg | 167 € | In Stock | |
| 50 mg | 282 € | In Stock | |
| 100 mg | 420 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 80 € | In Stock |
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CitedSelect Batch
Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ravoxertinib (GDC-0994) is an efficacious, orally available ERK1/2 inhibitor with an IC50 of 1.1/0.3 nM. |
| Targets&IC50 | ERK1:1.1 nM, ERK2:0.3 nM |
| In vitro | GDC-0994 significantly inhibits phospho-p90RSK in tumor cells. |
| In vivo | GDC-0994 (p.o.) inhibits intracellular ERK phosphorylation and activation of ERK-mediated signaling pathways, subsequently impeding the proliferation and survival of ERK-dependent tumor cells. In in vitro cancer models, GDC-0994 (p.o.) demonstrates significant single-dose efficacy, including against BRAF and KRAS mutant human xenograft tumors in mice. |
| Alias | GDC-0994 |
| Molecular Weight | 440.86 |
| Formula | C21H18ClFN6O2 |
| Cas No. | 1453848-26-4 |
| Smiles | Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1 |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 81 mg/mL (183.7 mM) DMSO: 81 mg/mL (183.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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