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Razoxane

Catalog No. T26046   CAS 21416-67-1

Razoxane is used as an antimitotic agent with immunosuppressive properties.

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Razoxane Chemical Structure
Razoxane, CAS 21416-67-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 157.00
5 mg In stock $ 317.00
10 mg In stock $ 447.00
25 mg In stock $ 738.00
50 mg In stock $ 987.00
100 mg In stock $ 1,380.00
1 mL * 10 mM (in DMSO) In stock $ 287.00
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Purity: 99.42%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Razoxane is used as an antimitotic agent with immunosuppressive properties.
In vivo This tumor model is characterized by osteoid formation and spontaneous metastasization to lungs, kidneys and lymph nodes. Razoxane given intraperitoneally (i.p.) from 2 days before to 14 days after tumor transplantation (30 mg/kg or 10 mg/kg per day) resulted in a dose-dependent prolongation of median survival time (83 or 48 days respectively, versus 38 days for the control group), but showed no influence on the growth of the primary tumor. Early treatment with razoxane (30 mg/kg i.p. from day -2 to +14) showed a greater inhibition of pulmonary metastases than later treatment (30 mg/kg i.p. from day +14 to +28 after transplantation). Whereas 59.9 per cent of the total sectional area of the lungs in the control animals was covered by osteosarcoma metastases, only 3.4 per cent and 26.1 per cent respectively was affected in the early and late razoxane treatment groups. Toxic side-effects of these treatment schedules were reversible diffuse alopecia, but no retardation of body weight gain[2].
Molecular Weight 268.27
Formula C11H16N4O4
CAS No. 21416-67-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (223.66 mM)

Related compound libraries

This product is contained In the following compound libraries:
DNA Damage & Repair Compound Library Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
CPT-Se3 Topoisomerase I inhibitor 9 Epirubicin hydrochloride CPT-Se4 Topoisomerase I inhibitor 10 α-Lapachone (±)-10-Hydroxycamptothecin Chloroquinoxaline sulfonamide

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Keywords

Razoxane 21416-67-1 DNA Damage/DNA Repair Topoisomerase ICRF 159 ICRF159 ICRF-159 Topoisomerase II Inhibitor RCC Inhibitor renal cell carcinoma inhibit inhibitor

 

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