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Retrorsine
Catalog No. TN2147Cas No. 480-54-6
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
Retrorsine
Catalog No. TN2147Cas No. 480-54-6
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury. |
| Targets&IC50 | OCT1:2.2 μM |
| In vitro | Retrorsine inhibited the OCT1-mediated 1-methyl-4-phenylpyridinium (MPP(+)) uptake in MDCK-hOCT1 cells with the IC50 of 2.25±0.30μM[1]. Retrorsine (60 μM, 120 μM , 240 μM; 24 h) significantly reduced HSEC-CYP3A4 cell viability and GSH levels and increases the formation of pyrrole-protein adducts[2]. |
| In vivo | In male Wistar rats, Retrorsine (30 mg/kg; i.p.; twice) impaired liver regeneration in the PBL model not only by an S or G2/M phase block but also by a block located before the G1/S transition of the cell cycle[3]. |
| Molecular Weight | 351.39 |
| Formula | C18H25NO6 |
| Cas No. | 480-54-6 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (270.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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