Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
Florosenine is a natural product of Senecio, Asteraceae. The catalog number is TN4068 and the CAS number is 16958-30-8. Florosenine can be used as a reference standard.
Sarracine N-oxide is a natural product of Senecio, Asteraceae. The catalog number is TN4952 and the CAS number is 19038-27-8. Sarracine N-oxide can be used as a reference standard.
Senecivernine is a natural product of Senecio, Asteraceae. The catalog number is TN4989 and the CAS number is 72755-25-0. Senecivernine can be used as a reference standard.
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.
1-Decarboxy-3-oxo-ceanothic acid exhibits in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, mediated at least in part by induction of apoptosis. It is cytotoxic against OVCAR-3 and HeLa cancer cell lines with IC50 values of 2.8 and 6.6 microg mL, respectively, and has an IC50 of 11.3 microg mL against normal cell line FS-5.
4-Hydroxy-4-(methoxycarbonylmethyl)cyclohexanone is a natural product for research related to life sciences. The catalog number is TN3037 and the CAS number is 81053-14-7.
Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.
Prenatal exposure to Integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring. Doses of Integerrimine N-oxide here employed did not produce marked immunotoxic effects.
Spartioidine is a natural product of Senecio, Asteraceae. The catalog number is TN5041 and the CAS number is 520-59-2. Spartioidine can be used as a reference standard.