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Rineterkib

Catalog No. T11224   CAS 1715025-32-3
Synonyms: ERK-IN-1

Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

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Rineterkib Chemical Structure
Rineterkib, CAS 1715025-32-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 96.00
5 mg In stock $ 198.00
10 mg In stock $ 372.00
25 mg In stock $ 629.00
50 mg In stock $ 896.00
100 mg In stock $ 1,220.00
1 mL * 10 mM (in DMSO) In stock $ 262.00
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Purity: 98.4%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
In vivo ERK-IN-1 (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice.
Synonyms ERK-IN-1
Molecular Weight 578.42
Formula C26H27BrF3N5O2
CAS No. 1715025-32-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (103.73 mM), Sonification is recommended

TargetMolReferences and Literature

1. CAPONIGRO, et al. THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR. WO2018051306A1.

TargetMolCitations

1. Liu P, Wang J, Peng S, et al. Suppression of phosphodiesterase IV enzyme by Roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anesthesia via PKA‐CREB and MEK/ERK pathways. European Journal of Neuroscience. 2022

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Kinase Inhibitor Library Anti-Lung Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Pancreatic Cancer Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Liver Cancer Compound Library

Related Products

Related compounds with same targets
Regorafenib B-Raf IN 13 GW 5074 Sorafenib Kobe0065 KRPEP-2D acetate LUT014 Ro 5126766

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Keywords

Rineterkib 1715025-32-3 MAPK Raf ERK G12V Extracellular signal regulated kinases G12D NSCLC inhibit G12C ERK-IN-1 KRAS Raf kinases Inhibitor inhibitor

 

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