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Rineterkib

Catalog No. T11224Cas No. 1715025-32-3
Alias ERK-IN-1

Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

Rineterkib

Rineterkib

Purity: 98.4%
Catalog No. T11224Alias ERK-IN-1Cas No. 1715025-32-3
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
Pack SizePriceAvailabilityQuantity
1 mg$96In Stock
5 mg$198In Stock
10 mg$372In Stock
25 mg$629In Stock
50 mg$896In Stock
100 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$262In Stock
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Purity:98.4%
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Product Introduction

Bioactivity
Description
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
In vivo
ERK-IN-1 (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice.
AliasERK-IN-1
Chemical Properties
Molecular Weight578.42
FormulaC26H27BrF3N5O2
Cas No.1715025-32-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (103.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7288 mL8.6442 mL17.2885 mL86.4424 mL
5 mM0.3458 mL1.7288 mL3.4577 mL17.2885 mL
10 mM0.1729 mL0.8644 mL1.7288 mL8.6442 mL
20 mM0.0864 mL0.4322 mL0.8644 mL4.3221 mL
50 mM0.0346 mL0.1729 mL0.3458 mL1.7288 mL
100 mM0.0173 mL0.0864 mL0.1729 mL0.8644 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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