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SAR407899

Catalog No. T7391 CAS 923359-38-0

SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.

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SAR407899, CAS 923359-38-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 52.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 153.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 393.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.91%

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Description	SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
Targets&IC50	ROCK2:102 nM (IC50), ROCK1:276 nM (IC50)
In vivo	In vivo, SAR407899 dose-dependently induced rabbit penile erection, with greater potency and longer duration of action than sildenafil[1].
Animal Research	Compared the effects of SAR407899, the Rho-kinase inhibitor Y-27632 and the PDE5 inhibitor sildenafil for their ability to relax corpus cavernosum strips contracted with phenylephrine in healthy and diabetic animals. Strips were obtained from WKY, spontaneous hypertensive (SHR), control CD, and diabetic CD rats, humans, control and diabetic rabbits. Diabetes was induced by streptozotocin or alloxan injection. In vivo penile erection (length) induced by drugs was measured in conscious rabbits[1].

Molecular Weight	244.29
Formula	C14H16N2O2
CAS No.	923359-38-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6 mg/mL (24.56 mM)

References and Literature

1. Guagnini F , Ferazzini M , Grasso M , et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa[J]. Journal of Translational Medicine, 2012, 10(1):59-0. 2. Grisk O, Schlüter T, Reimer N, et al.The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries[J].J Hypertens. 2012 May;30(5):980-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library TGF-beta/Smad Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Clinical Compound Library Anti-Diabetic Compound Library Cell Cycle Compound Library Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library

Related Products

Related compounds with same targets

ROCK-IN-2 Y-27632 CID-5056270 CKI-7 ZINC00881524 CCG-232964 Neoprzewaquinone A URMC-099

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

SAR407899 923359-38-0 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK Rho Rho-associated kinase ROK SAR-407899 Rho-kinase Rho-associated protein kinase SAR 407899 inhibit Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.