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SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $33 | In Stock | |
10 mg | $58 | In Stock | |
25 mg | $128 | In Stock | |
50 mg | $198 | In Stock | |
100 mg | $335 | In Stock | |
200 mg | $479 | In Stock | |
1 mL x 10 mM (in DMSO) | $53 | In Stock |
Description | SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic |
Targets&IC50 | COX-2:0.04 μM |
In vitro | SC-58125 treatment on the growth of human colon carcinoma cells in nude mice.?Delaying treatment by 2, 4, or 7 weeks following implantation of the carcinoma cells resulted in a significant inhibition of tumor growth.?Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days.?SC-58125 treatment did not alter the rate at which cells underwent apoptosis, but did result in a delayed progression through the cell cycle at the G(2)/M transition.?Accordingly, p34(cdc2) protein levels and activity were decreased following SC-58125 treatment.SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G(2)/M phase of the cell cycle |
Alias | SC 58125 |
Molecular Weight | 384.35 |
Formula | C17H12F4N2O2S |
Cas No. | 162054-19-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 9 mg/mL (23.42 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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