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SC-58125

Catalog No. T23333Cas No. 162054-19-5
Alias SC 58125

SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic

SC-58125

SC-58125

Purity: 99.81%
Catalog No. T23333Alias SC 58125Cas No. 162054-19-5
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic
Pack SizePriceAvailabilityQuantity
5 mg$33In Stock
10 mg$58In Stock
25 mg$128In Stock
50 mg$198In Stock
100 mg$335In Stock
200 mg$479In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic
Targets&IC50
COX-2:0.04 μM
In vitro
SC-58125 treatment on the growth of human colon carcinoma cells in nude mice.?Delaying treatment by 2, 4, or 7 weeks following implantation of the carcinoma cells resulted in a significant inhibition of tumor growth.?Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days.?SC-58125 treatment did not alter the rate at which cells underwent apoptosis, but did result in a delayed progression through the cell cycle at the G(2)/M transition.?Accordingly, p34(cdc2) protein levels and activity were decreased following SC-58125 treatment.SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G(2)/M phase of the cell cycle
AliasSC 58125
Chemical Properties
Molecular Weight384.35
FormulaC17H12F4N2O2S
Cas No.162054-19-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9 mg/mL (23.42 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6018 mL13.0090 mL26.0180 mL130.0898 mL
5 mM0.5204 mL2.6018 mL5.2036 mL26.0180 mL
10 mM0.2602 mL1.3009 mL2.6018 mL13.0090 mL
20 mM0.1301 mL0.6504 mL1.3009 mL6.5045 mL

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