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SI-113

Catalog No. T9589Cas No. 1392816-46-4

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

SI-113

SI-113

Purity: 98.81%
Catalog No. T9589Cas No. 1392816-46-4
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$54In Stock
5 mg$89In Stock
10 mg$143In Stock
25 mg$263In Stock
50 mg$393In Stock
100 mg$576In Stock
1 mL x 10 mM (in DMSO)$108In Stock
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Purity:98.81%
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Product Introduction

Bioactivity
Description
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
In vitro
Cell viability, cell death, caspase activation and cell cycle progression were then analyzed by FACS and WB-based assays, after exposure to SI113, with or without oxidative stress and ionizing radiations. Moreover, autophagy and related reticulum stress response were evaluated. We show here, that i) SGK1 is over-expressed in highly malignant gliomas and that the treatment with SI113 leads to ii) significant increase in caspase-mediated apoptotic cell death in GBM cell lines but not in normal fibroblasts; iii)enhancement of the effects of ionizing radiations; iv) modulation of the response to oxidative reticulum stress; v) induction of cytotoxic autophagy[2].
Chemical Properties
Molecular Weight400.48
FormulaC23H24N6O
Cas No.1392816-46-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/mL (162.31 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4970 mL12.4850 mL24.9700 mL124.8502 mL
5 mM0.4994 mL2.4970 mL4.9940 mL24.9700 mL
10 mM0.2497 mL1.2485 mL2.4970 mL12.4850 mL
20 mM0.1249 mL0.6243 mL1.2485 mL6.2425 mL
50 mM0.0499 mL0.2497 mL0.4994 mL2.4970 mL
100 mM0.0250 mL0.1249 mL0.2497 mL1.2485 mL

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