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SI-113

Catalog No. T9589   CAS 1392816-46-4

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

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SI-113 Chemical Structure
SI-113, CAS 1392816-46-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 38.00
2 mg In stock $ 54.00
5 mg In stock $ 89.00
10 mg In stock $ 143.00
25 mg In stock $ 263.00
50 mg In stock $ 393.00
100 mg In stock $ 576.00
1 mL * 10 mM (in DMSO) In stock $ 108.00
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Purity: 98.81%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
In vitro Cell viability, cell death, caspase activation and cell cycle progression were then analyzed by FACS and WB-based assays, after exposure to SI113, with or without oxidative stress and ionizing radiations. Moreover, autophagy and related reticulum stress response were evaluated. We show here, that i) SGK1 is over-expressed in highly malignant gliomas and that the treatment with SI113 leads to ii) significant increase in caspase-mediated apoptotic cell death in GBM cell lines but not in normal fibroblasts; iii)enhancement of the effects of ionizing radiations; iv) modulation of the response to oxidative reticulum stress; v) induction of cytotoxic autophagy[2].
Molecular Weight 400.48
Formula C23H24N6O
CAS No. 1392816-46-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (162.31 mM)

TargetMolReferences and Literature

1. Matteoni S, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. 2. Talarico C, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016 Mar 29;7(13):15868-84.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compound Library Glycometabolism Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library

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Keywords

SI-113 1392816-46-4 Metabolism SGK SI 113 SI113 inhibitor inhibit

 

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