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SP-8356
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SP-8356
Catalog No. T12981Cas No. 1454885-45-0
SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $106 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $417 | In Stock | |
| 25 mg | $788 | In Stock | |
| 50 mg | $1,070 | In Stock | |
| 100 mg | $1,430 | In Stock | |
| 500 mg | $2,890 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $296 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147),and is an anti-inflammatory synthetic verbenone derivative, with anti-atherosclerotic effects. |
| In vitro | In a time- and dose-dependent manner, SP-8356 (5-10 μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10 μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP [1]. |
| In vivo | In a xenograft mouse model, SP-8356 (10mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth [1]. SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability [2]. |
| Molecular Weight | 300.35 |
| Formula | C18H20O4 |
| Cas No. | 1454885-45-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (199.77 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Dose Conversion
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