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SR0987

Catalog No. T4670 CAS 303126-97-8

Purity 99.43% Datasheet

SR0987 is a RORγt agonist,

SR0987, CAS 303126-97-8

Pack Size	Availability	Price/USD
5 mg	In stock	77.00
10 mg	In stock	131.00
25 mg	In stock	266.00
50 mg	In stock	446.00
100 mg	In stock	797.00
1 mL * 10 mM (in DMSO)	In stock	84.00

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Purity 99.43%

HNMR LCMS COA Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SR0987 is a RORγt agonist,
Targets&IC50	RORγt :ic50 800 nM (EC50),
In vitro	SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM.

Molecular Weight	397.7
Formula	C16H10ClF6NO2
CAS No.	303126-97-8

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

2. Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-cancer Compound Library

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TAK-828F Xylan Vimirogant AZD-0284 RORγt Inverse agonist 8 A-9758 S18-000003 FM26

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.