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SR59230A

Catalog No. T13016 CAS 174689-39-5

SR59230A is a potent, selective antagonist of β3-adrenergic receptor(β3, β1, and β2 receptors with IC50s of 40, 408, and 648 nM , respectively).

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SR59230A, CAS 174689-39-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 70.00
5 mg	In stock	$ 109.00
10 mg	In stock	$ 182.00
25 mg	In stock	$ 361.00
50 mg	In stock	$ 537.00
100 mg	In stock	$ 775.00
1 mL * 10 mM (in DMSO)	In stock	$ 127.00

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Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SR59230A is a potent, selective antagonist of β3-adrenergic receptor(β3, β1, and β2 receptors with IC50s of 40, 408, and 648 nM , respectively).
Targets&IC50	β1-adrenoceptor:408 nM , β3-adrenoceptor:40 nM , β2-adrenoceptor:648 nM
In vitro	The specific antagonism of β3-AR by SR59230A inhibits NB growth and tumor progression, by switching from stemness to cell differentiation both in vivo and in vitro through the specific blockade of SK2/S1P2 signaling[1].

Molecular Weight	415.48
Formula	C23H29NO6
CAS No.	174689-39-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (72.21 mM)

References and Literature

1. Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384. 2. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Inhibitor Library Anti-Cardiovascular Disease Compound Library Endocrinology-Hormone Compound Library NO PAINS Compound Library Adrenergic Receptor-Targeted Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Bioactive Compound Library

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Keywords

SR59230A 174689-39-5 GPCR/G Protein Neuroscience Adrenergic Receptor hyperthermia adrenoceptor adrenergic Beta Receptor inhibit hypothermia receptor Inhibitor SR-59230A inhibitor

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