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Silybin B

Catalog No. TN2211 CAS 142797-34-0

Synonyms: 水飞蓟宾A+B, 水飞蓟宾B

Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibition and apoptosis induction in human chronic myeloid leukemia K562 cells. Silybin B exhibits 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity.

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Silybin B, CAS 142797-34-0

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Purity: 98%

Biological Description

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Description

In vitro

The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.

Synonyms	水飞蓟宾A+B, 水飞蓟宾B
Molecular Weight	482.44
Formula	C25H22O10
CAS No.	142797-34-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells.Nat Prod Commun. 2011 Nov;6(11):1653-6.

Citations

1. An Y, Zhu J, Wang X, et al. Oridonin Delays Aging Through the AKT Signaling Pathway. Frontiers in Pharmacology. 2022: 1823

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Keywords

Silybin B 142797-34-0 代谢离子通道免疫与炎症 Calcium Channel ROS Inhibitor inhibitor inhibit

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