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Silybin B

Catalog No. TN2211 CAS 142797-34-0

Synonyms: Silibinin B

Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis.

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Silybin B, CAS 142797-34-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 493.00
25 mg	In stock	$ 788.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 349.00

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Purity: 99.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis.
In vitro	The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.[1]
In vivo	Silybin B markedly improved the behavioral abnormalities in cisplatin-treated mice and reduced LPO levels while increasing SOD, GSH, and T-AOC in mice brain tissue. Nissl staining and Tunel assay showed that silybin B alleviated cisplatin-induced hippocampal damage.[2]

Synonyms	Silibinin B
Molecular Weight	482.44
Formula	C25H22O10
CAS No.	142797-34-0

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (466.4 mM), Sonication is recommended.

References and Literature

1. Zhang J, et al. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Nat Prod Commun. 2011;6(11):1653-1656. 2. Wang XL, et al. Silybin B exerts protective effect on cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. J Ethnopharmacol. 2022;288:114938.

Related compound libraries

This product is contained In the following compound libraries：

Rare Natural Product Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Silybin B 142797-34-0 Angiogenesis Apoptosis Cytoskeletal Signaling Neuroscience Tyrosine Kinase/Adaptors Bcr-Abl Beta Amyloid Silibinin B inhibitor inhibit

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