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Spinorphin

Catalog No. T8455 CAS 137201-62-8

Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.

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Spinorphin, CAS 137201-62-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 132.00
5 mg	In stock	$ 257.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00

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Purity: 100%

Biological Description

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Description	Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
In vitro	Spinorphin inhibited cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons.?Spinorphin (10-300 M) inhibited the Ca(2+) signals in concentration dependant manner in small- and medium diameter DRG neurons.?Capsaicin produced [Ca(2+)]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca(2+)]i responses[1].
In vivo	Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2].

Molecular Weight	877
Formula	C45H64N8O10
CAS No.	137201-62-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Ayar A , Ozcan M , Kemal Tuğrul Kuzgun, et al. Spinorphin inhibits membrane depolarization- and capsaicin-induced intracellular calcium signals in rat primary nociceptive dorsal root ganglion neurons in culture[J]. Journal of Receptor Research, 2015, 35(6):550-558. 2. YAMAMOTO,Y. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation.[J]. Current Protn & Peptide ence, 2002, 3(6):-.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Peptide Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Endocrinology-Hormone Compound Library

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Keywords

Spinorphin 137201-62-8 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor inhibit Inhibitor inhibitor

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