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Spinorphin

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Purity:100%

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COA LCMS

Spinorphin

Catalog No. T8455Cas No. 137201-62-8

Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.

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Pack Size	Price	Availability
1 mg	$132	In Stock
5 mg	$257	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock

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Product Introduction

Bioactivity

Description	Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
In vitro	Spinorphin inhibited cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons.?Spinorphin (10-300 M) inhibited the Ca(2+) signals in concentration dependant manner in small- and medium diameter DRG neurons.?Capsaicin produced [Ca(2+)]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca(2+)]i responses[1].
In vivo	Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2].

Chemical Properties

Molecular Weight	877
Formula	C45H64N8O10
Cas No.	137201-62-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (57.01 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1403 mL	5.7013 mL	11.4025 mL	57.0125 mL
5 mM	0.2281 mL	1.1403 mL	2.2805 mL	11.4025 mL
10 mM	0.1140 mL	0.5701 mL	1.1403 mL	5.7013 mL
20 mM	0.0570 mL	0.2851 mL	0.5701 mL	2.8506 mL
50 mM	0.0228 mL	0.1140 mL	0.2281 mL	1.1403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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